uniprotkb:Q9Z2I6	uniprotkb:P0DPI0	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Mahrhold et al. (2006)	pubmed:16545378|imex:IM-13944|mint:MINT-5218441	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-8178884|mint:MINT-1795489|imex:IM-13944-1	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC|mint:MINT-1795491(identity)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968|mint:MINT-1795490(identity)"	-	"comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA|comment:""\""Stoichiometry: 1.0\"""""	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\""""|comment:""\""Stoichiometry: 1.0\"""""	figure legend:F1B|figure legend:F1C|figure legend:F2|comment:mint|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2024/11/14	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	intact-crc:4CACA8B56E8DCCEB|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	binding-associated region:454-603(MINT-1795502)|glutathione s tranferase tag:?-?(MINT-1795496)	binding-associated region:448-1295(MINT-1795511)|tag:?-?(MINT-1795505)	1	1	"psi-mi:""MI:0078""(nucleotide sequence identification)"	"psi-mi:""MI:0078""(nucleotide sequence identification)"
uniprotkb:P29101	uniprotkb:P10844	intact:EBI-458017	intact:EBI-7661991|uniprotkb:P10843|intact:MINT-1795550	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:bxb_clobo(display_long)|uniprotkb:botB(gene name)|psi-mi:botB(display_short)|uniprotkb:Bontoxilysin-B(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Mahrhold et al. (2006)	pubmed:16545378|imex:IM-13944|mint:MINT-5218441	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-8178984|mint:MINT-1795514|imex:IM-13944-2	intact-miscore:0.77	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)|mint:MINT-1795524(identity)"	"refseq:WP_012291519.1|dip:DIP-42782N|mint:P10844|rcsb pdb:1F31|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1EPW|rcsb pdb:1F82|rcsb pdb:1G9A|rcsb pdb:1G9B|rcsb pdb:1G9C|rcsb pdb:1G9D|rcsb pdb:1I1E|rcsb pdb:1S0B|rcsb pdb:1S0C|rcsb pdb:1S0D|rcsb pdb:1S0E|rcsb pdb:1S0F|rcsb pdb:1S0G|rcsb pdb:1Z0H|rcsb pdb:2ETF|rcsb pdb:2NM1|rcsb pdb:2NP0|rcsb pdb:2XHL|rcsb pdb:3ZUQ|rcsb pdb:4KBB|rcsb pdb:5VID|rcsb pdb:5VMR|rcsb pdb:6G5F|rcsb pdb:6G5G|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6UC6|rcsb pdb:6UFT|rcsb pdb:6UHT|rcsb pdb:6UL4|rcsb pdb:7NA9|rcsb pdb:7QFQ|rcsb pdb:7T5F|reactome:R-HSA-5250958|mint:MINT-1795515(identity)"	-	"comment:""\""Stoichiometry: 1.0\"""""	"comment:mint|function:""\""Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2\""""|comment:""\""Stoichiometry: 1.0\"""""	figure legend:F2|comment:mint|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2024/11/14	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	rogid:TyP1/JJzdgNBsIqolX4P5Vc+9Ag1491	intact-crc:ECA6134C397EBD9D|rigid:5VTvp7jz8LSWDObE8OcmI6JyJJQ	false	glutathione s tranferase tag:?-?(MINT-1795531)|binding-associated region:1-90(MINT-1795525)	tag:?-?(MINT-1795522)|binding-associated region:441-1290(MINT-1795516)	1	1	"psi-mi:""MI:0078""(nucleotide sequence identification)"	"psi-mi:""MI:0078""(nucleotide sequence identification)"
uniprotkb:A5JGM8	uniprotkb:P21707	intact:EBI-16067725	intact:EBI-458098|uniprotkb:Q3S2E6|uniprotkb:Q707P5|ensembl:ENSRNOP00000049624.2	psi-mi:a5jgm8_clobo(display_long)|uniprotkb:bont(gene name)|psi-mi:bont(display_short)|uniprotkb:boNT D(gene name synonym)|uniprotkb:C(gene name synonym)|uniprotkb:DC(gene name synonym)|uniprotkb:NT(gene name synonym)	psi-mi:syt1_rat(display_long)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Berntsson et al. (2013)	pubmed:23932591|doi:10.1016/j.str.2013.06.026|imex:IM-21900	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0914""(association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-16067747|imex:IM-21900-1|dip:DIP-192442E	intact-miscore:0.35	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"dip:DIP-60561N|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:5LR0"	"rgd:3803|refseq:NP_001028852.2|ensembl:ENSRNOG00000006426.7(gene)|ensembl:ENSRNOT00000048880.3(transcript)|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005513""(detection of calcium ion)|go:""GO:0005516""(calmodulin binding)|go:""GO:0005543""(phospholipid binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005546""(phosphatidylinositol-4,5-bisphosphate binding)|go:""GO:0005737""(cytoplasm)|go:""GO:0005794""(Golgi apparatus)|go:""GO:0005886""(plasma membrane)|go:""GO:0006906""(vesicle fusion)|go:""GO:0007269""(neurotransmitter secretion)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0008289""(lipid binding)|go:""GO:0014059""(regulation of dopamine secretion)|go:""GO:0014069""(postsynaptic density)|go:""GO:0016050""(vesicle organization)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017075""(syntaxin-1 binding)|go:""GO:0017156""(calcium-ion regulated exocytosis)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030141""(secretory granule)|go:""GO:0030154""(cell differentiation)|go:""GO:0030276""(clathrin binding)|go:""GO:0030348""(syntaxin-3 binding)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031338""(regulation of vesicle fusion)|go:""GO:0031340""(positive regulation of vesicle fusion)|go:""GO:0033603""(positive regulation of dopamine secretion)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0042734""(presynaptic membrane)|go:""GO:0042802""(identical protein binding)|go:""GO:0043005""(neuron projection)|go:""GO:0043195""(terminal bouton)|go:""GO:0044306""(neuron projection terminus)|go:""GO:0045211""(postsynaptic membrane)|go:""GO:0045956""(positive regulation of calcium ion-dependent exocytosis)|go:""GO:0046982""(protein heterodimerization activity)|go:""GO:0048278""(vesicle docking)|go:""GO:0048306""(calcium-dependent protein binding)|go:""GO:0048786""(presynaptic active zone)|go:""GO:0048791""(calcium ion-regulated exocytosis of neurotransmitter)|go:""GO:0050750""(low-density lipoprotein particle receptor binding)|go:""GO:0050806""(positive regulation of synaptic transmission)|go:""GO:0051291""(protein heterooligomerization)|go:""GO:0051592""(response to calcium ion)|go:""GO:0051966""(regulation of synaptic transmission, glutamatergic)|go:""GO:0060076""(excitatory synapse)|go:""GO:0061669""(spontaneous neurotransmitter secretion)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0071277""(cellular response to calcium ion)|go:""GO:0071911""(synchronous neurotransmitter secretion)|go:""GO:0098686""(hippocampal mossy fiber to CA3 synapse)|go:""GO:0098746""(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:0099523""(presynaptic cytosol)|go:""GO:0099524""(postsynaptic cytosol)|go:""GO:0140693""(molecular condensate scaffold activity)|go:""GO:0140694""(membraneless organelle assembly)|go:""GO:1903235""(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:""GO:1903305""(regulation of regulated secretory pathway)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|mint:P21707|rcsb pdb:1BYN|rcsb pdb:1K5W|rcsb pdb:1RSY|rcsb pdb:1TJM|rcsb pdb:1TJX|rcsb pdb:1UOV|rcsb pdb:1UOW|rcsb pdb:2YOA|rcsb pdb:4WEE|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5CCJ|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6CXW|rcsb pdb:6MTI|rcsb pdb:8C5H|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-888590|refseq:XP_017450168.1|dip:DIP-29064N|panther:PTHR10024(orthology-group)"	"psi-mi:""MI:0465""(dip)"	-	-	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2025/01/27	rogid:OreS102Dko4/mgYvmRiUYvkQZqk1491	rogid:fr7zfj22zAOY/bJ7psjrgnsb0g810116	intact-crc:7D2FA8269C3C09E9|rigid:9/xINfiaELyZTMEBfafpgFgTgP8	false	sufficient binding region:859-1285|mutation disrupting interaction strength:1191-1191|mutation disrupting interaction strength:1264-1264|mutation disrupting interaction strength:1179-1179|mutation decreasing interaction strength:1182-1182|mutation decreasing interaction strength:1235-1235|glutathione s tranferase tag:n-n	-	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:A5JGM8	uniprotkb:P29101	intact:EBI-16067725	intact:EBI-458017	psi-mi:a5jgm8_clobo(display_long)|uniprotkb:bont(gene name)|psi-mi:bont(display_short)|uniprotkb:boNT D(gene name synonym)|uniprotkb:C(gene name synonym)|uniprotkb:DC(gene name synonym)|uniprotkb:NT(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Berntsson et al. (2013)	pubmed:23932591|doi:10.1016/j.str.2013.06.026|imex:IM-21900	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0914""(association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-16067747|imex:IM-21900-1|dip:DIP-192442E	intact-miscore:0.52	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"dip:DIP-60561N|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:5LR0"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)"	"psi-mi:""MI:0465""(dip)"	-	-	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2025/01/27	rogid:OreS102Dko4/mgYvmRiUYvkQZqk1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:7D2FA8269C3C09E9|rigid:9/xINfiaELyZTMEBfafpgFgTgP8	false	sufficient binding region:859-1285|mutation disrupting interaction strength:1191-1191|mutation disrupting interaction strength:1264-1264|mutation disrupting interaction strength:1179-1179|mutation decreasing interaction strength:1182-1182|mutation decreasing interaction strength:1235-1235|glutathione s tranferase tag:n-n	-	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:A5JGM8	uniprotkb:P29101	intact:EBI-16067725	intact:EBI-458017	psi-mi:a5jgm8_clobo(display_long)|uniprotkb:bont(gene name)|psi-mi:bont(display_short)|uniprotkb:boNT D(gene name synonym)|uniprotkb:C(gene name synonym)|uniprotkb:DC(gene name synonym)|uniprotkb:NT(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	"psi-mi:""MI:0114""(x-ray crystallography)"	Berntsson et al. (2013)	pubmed:23932591|doi:10.1016/j.str.2013.06.026|imex:IM-21900	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-16067785|imex:IM-21900-2|dip:DIP-192443E	intact-miscore:0.52	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"dip:DIP-60561N|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:5LR0"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)"	"psi-mi:""MI:0465""(dip)"	-	-	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2024/11/14	rogid:OreS102Dko4/mgYvmRiUYvkQZqk1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:F379DF1BA012CCBF|rigid:xRKOOFQpO1bWlVeWRMQhjD/LTxQ	false	sufficient binding region:859-1285	sufficient binding region:40-60	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:O08816	uniprotkb:P0DJ88	intact:EBI-6142604	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:esfu2_eco57(display_long)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)"	"psi-mi:""MI:0096""(pull down)"	Sallee et al. (2008)	pubmed:18650806|doi:10.1038/nature07170|imex:IM-17993	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-15717659|imex:IM-17993-1|dip:DIP-189577E	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	"go:""GO:0005576""(extracellular region)|interpro:IPR006891(EspF protein)|go:""GO:0030430""(host cell cytoplasm)|go:""GO:0009405""(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N"	"psi-mi:""MI:0465""(dip)"	-	caution:This sequence has been withdrawn from Uniprot.	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2024/11/14	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	rogid:WARX33S3/G5CXG922GIjofxveNc83334	intact-crc:0D334A38B14E82C8|rigid:c0LdFPSux2XWLpoaenuBKr/Ts08	false	sufficient binding region:228-270|glutathione s tranferase tag:n-n	binding-associated region:221-267|his tag:n-n	-	-	"psi-mi:""MI:0705""(anti tag western blot)"	"psi-mi:""MI:0705""(anti tag western blot)"
uniprotkb:O08816	uniprotkb:P0DJ88	intact:EBI-6142604	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:esfu2_eco57(display_long)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)"	"psi-mi:""MI:0053""(fluorescence polarization spectroscopy)"	Sallee et al. (2008)	pubmed:18650806|doi:10.1038/nature07170|imex:IM-17993	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-15717684|imex:IM-17993-2|dip:DIP-189577E	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	"go:""GO:0005576""(extracellular region)|interpro:IPR006891(EspF protein)|go:""GO:0030430""(host cell cytoplasm)|go:""GO:0009405""(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N"	"psi-mi:""MI:0465""(dip)"	-	caution:This sequence has been withdrawn from Uniprot.	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2024/11/14	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	rogid:WARX33S3/G5CXG922GIjofxveNc83334	intact-crc:CFA70C958F2CBC8B|rigid:c0LdFPSux2XWLpoaenuBKr/Ts08	false	fluorescein isothiocyanate label:236-236|binding-associated region:226-274	sufficient binding region:80-126	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:O08816	uniprotkb:P0DJ88	intact:EBI-6142604	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:esfu2_eco57(display_long)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)"	"psi-mi:""MI:0096""(pull down)"	Sallee et al. (2008)	pubmed:18650806|doi:10.1038/nature07170|imex:IM-17993	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-15717732|imex:IM-17993-4|dip:DIP-189577E	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	"go:""GO:0005576""(extracellular region)|interpro:IPR006891(EspF protein)|go:""GO:0030430""(host cell cytoplasm)|go:""GO:0009405""(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N"	"psi-mi:""MI:0465""(dip)"	-	caution:This sequence has been withdrawn from Uniprot.	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2024/11/14	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	rogid:WARX33S3/G5CXG922GIjofxveNc83334	intact-crc:7228011F552A8843|rigid:c0LdFPSux2XWLpoaenuBKr/Ts08	false	his tag:n-n|binding-associated region:190-274	sufficient binding region:221-237|glutathione s tranferase tag:n-n|sufficient binding region:80-173	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:O08816	uniprotkb:P0DJ88	intact:EBI-6142604	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:esfu2_eco57(display_long)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)"	"psi-mi:""MI:0028""(cosedimentation in solution)"	Sallee et al. (2008)	pubmed:18650806|doi:10.1038/nature07170|imex:IM-17993	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-15717759|imex:IM-17993-5|dip:DIP-189577E	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	"go:""GO:0005576""(extracellular region)|interpro:IPR006891(EspF protein)|go:""GO:0030430""(host cell cytoplasm)|go:""GO:0009405""(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N"	"psi-mi:""MI:0465""(dip)"	-	caution:This sequence has been withdrawn from Uniprot.	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2024/11/14	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	rogid:WARX33S3/G5CXG922GIjofxveNc83334	intact-crc:EC5326C08AAE00AB|rigid:c0LdFPSux2XWLpoaenuBKr/Ts08	false	binding-associated region:178-274|binding-associated region:392-501	sufficient binding region:80-173	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:B7UR60	uniprotkb:P31016	intact:EBI-25435618	intact:EBI-375655|uniprotkb:P97631	psi-mi:b7ur60_eco27(display_long)|uniprotkb:E2348C_1442(locus name)	psi-mi:dlg4_rat(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:Psd95(gene name synonym)	"psi-mi:""MI:0089""(protein array)"	Lee et al. (2008)	pubmed:17979986|imex:IM-28455	"taxid:574521(eco27)|taxid:574521(""Escherichia coli O127:H6 (strain E2348/69 / EPEC)"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-26429867|imex:IM-28455-15	intact-miscore:0.44	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	mint:B7UR60|refseq:WP_001025663.1	"mint:P31016|rgd:68424|refseq:NP_062567.1|go:""GO:0002091""(negative regulation of receptor internalization)|go:""GO:0005102""(signaling receptor binding)|go:""GO:0005109""(frizzled binding)|go:""GO:0005737""(cytoplasm)|go:""GO:0005783""(endoplasmic reticulum)|go:""GO:0005829""(cytosol)|go:""GO:0005886""(plasma membrane)|go:""GO:0005911""(cell-cell junction)|go:""GO:0007204""(positive regulation of cytosolic calcium ion concentration)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0007399""(nervous system development)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0014069""(postsynaptic density)|go:""GO:0016020""(membrane)|go:""GO:0016188""(synaptic vesicle maturation)|go:""GO:0016323""(basolateral plasma membrane)|go:""GO:0019894""(kinesin binding)|go:""GO:0019900""(kinase binding)|go:""GO:0019901""(protein kinase binding)|go:""GO:0019903""(protein phosphatase binding)|go:""GO:0021987""(cerebral cortex development)|go:""GO:0030054""(cell junction)|go:""GO:0030165""(PDZ domain binding)|go:""GO:0030425""(dendrite)|go:""GO:0030863""(cortical cytoskeleton)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0031697""(beta-1 adrenergic receptor binding)|go:""GO:0031698""(beta-2 adrenergic receptor binding)|go:""GO:0031748""(D1 dopamine receptor binding)|go:""GO:0031812""(P2Y1 nucleotide receptor binding)|go:""GO:0032281""(AMPA glutamate receptor complex)|go:""GO:0032839""(dendrite cytoplasm)|go:""GO:0033130""(acetylcholine receptor binding)|go:""GO:0035176""(social behavior)|go:""GO:0035254""(glutamate receptor binding)|go:""GO:0035255""(ionotropic glutamate receptor binding)|go:""GO:0035418""(protein localization to synapse)|go:""GO:0035641""(locomotory exploration behavior)|go:""GO:0035865""(cellular response to potassium ion)|go:""GO:0043005""(neuron projection)|go:""GO:0043197""(dendritic spine)|go:""GO:0044224""(juxtaparanode region of axon)|go:""GO:0044300""(cerebellar mossy fiber)|go:""GO:0044306""(neuron projection terminus)|go:""GO:0044307""(dendritic branch)|go:""GO:0044309""(neuron spine)|go:""GO:0044877""(protein-containing complex binding)|go:""GO:0045161""(neuronal ion channel clustering)|go:""GO:0045184""(establishment of protein localization)|go:""GO:0045197""(establishment or maintenance of epithelial cell apical/basal polarity)|go:""GO:0045202""(synapse)|go:""GO:0045211""(postsynaptic membrane)|go:""GO:0048168""(regulation of neuronal synaptic plasticity)|go:""GO:0048169""(regulation of long-term neuronal synaptic plasticity)|go:""GO:0050775""(positive regulation of dendrite morphogenesis)|go:""GO:0050806""(positive regulation of synaptic transmission)|go:""GO:0050885""(neuromuscular process controlling balance)|go:""GO:0051965""(positive regulation of synapse assembly)|go:""GO:0060076""(excitatory synapse)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0065003""(protein-containing complex assembly)|go:""GO:0071625""(vocalization behavior)|go:""GO:0071944""(cell periphery)|go:""GO:0097060""(synaptic membrane)|go:""GO:0097061""(dendritic spine organization)|go:""GO:0097109""(neuroligin family protein binding)|go:""GO:0097110""(scaffold protein binding)|go:""GO:0097113""(AMPA glutamate receptor clustering)|go:""GO:0097120""(receptor localization to synapse)|go:""GO:0098609""(cell-cell adhesion)|go:""GO:0098794""(postsynapse)|go:""GO:0098839""(postsynaptic density membrane)|go:""GO:0098919""(structural constituent of postsynaptic density)|go:""GO:0098970""(postsynaptic neurotransmitter receptor diffusion trapping)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0098989""(NMDA selective glutamate receptor signaling pathway)|go:""GO:0099645""(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:""GO:0150012""(positive regulation of neuron projection arborization)|go:""GO:1904719""(positive regulation of AMPA glutamate receptor clustering)|go:""GO:1990635""(proximal dendrite)|go:""GO:2000310""(regulation of NMDA receptor activity)|go:""GO:2000463""(positive regulation of excitatory postsynaptic potential)|go:""GO:2000821""(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313(""Membrane-associated guanylate kinase (MAGUK) scaffold protein"")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR050614|rcsb pdb:1BE9|rcsb pdb:1BFE|rcsb pdb:1IU0|rcsb pdb:1IU2|rcsb pdb:1JXM|rcsb pdb:1JXO|rcsb pdb:1KJW|rcsb pdb:1QLC|rcsb pdb:1RGR|rcsb pdb:1TP3|rcsb pdb:1TP5|rcsb pdb:1TQ3|rcsb pdb:2KA9|rcsb pdb:2MHO|rcsb pdb:2XKX|rcsb pdb:3GSL|rcsb pdb:3WP0|rcsb pdb:3WP1|rcsb pdb:5B64|rcsb pdb:5D13|rcsb pdb:5GNV|rcsb pdb:5HDY|rcsb pdb:5HEB|rcsb pdb:5HED|rcsb pdb:5HET|rcsb pdb:5HEY|rcsb pdb:5HF1|rcsb pdb:5HF4|rcsb pdb:5HFB|rcsb pdb:5HFC|rcsb pdb:5HFD|rcsb pdb:5HFE|rcsb pdb:5HFF|rcsb pdb:5MZ7|rcsb pdb:5W72|rcsb pdb:5YPO|rcsb pdb:5YPR|rcsb pdb:7CQF|rcsb pdb:7F7G|rcsb pdb:7F7I|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5625900|reactome:R-RNO-5673001|reactome:R-RNO-5682910|reactome:R-RNO-6794361|reactome:R-RNO-8849932|dip:DIP-29264N|panther:PTHR23119(orthology-group)"	-	-	-	figure legend:fig. 1b,1c table 2|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/13	2024/11/14	rogid:9JzwwZQrNraeZGU9Yv2lBn78En8574521	rogid:4oWbxT/HVvWQqdbFqt3htRuQNpw10116	intact-crc:770159A868BFFBEC|rigid:f8TwVhFs5SVS9995nh3LhEfZNFY	false	binding-associated region:391-440|glutathione s tranferase tag:?-?	binding-associated region:59-303|his tag:?-?	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0707""(anti tag immunostaining)"
uniprotkb:B7UR60	uniprotkb:Q62696	intact:EBI-25435618	intact:EBI-389325	psi-mi:b7ur60_eco27(display_long)|uniprotkb:E2348C_1442(locus name)	psi-mi:dlg1_rat(display_long)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Dlgh1(gene name synonym)	"psi-mi:""MI:0089""(protein array)"	Lee et al. (2008)	pubmed:17979986|imex:IM-28455	"taxid:574521(eco27)|taxid:574521(""Escherichia coli O127:H6 (strain E2348/69 / EPEC)"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-26429878|imex:IM-28455-17	intact-miscore:0.44	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	mint:B7UR60|refseq:WP_001025663.1	"rgd:2505|refseq:NP_036920.1|go:""GO:0000122""(negative regulation of transcription by RNA polymerase II)|go:""GO:0001657""(ureteric bud development)|go:""GO:0001658""(branching involved in ureteric bud morphogenesis)|go:""GO:0001771""(immunological synapse formation)|go:""GO:0001772""(immunological synapse)|go:""GO:0001935""(endothelial cell proliferation)|go:""GO:0002088""(lens development in camera-type eye)|go:""GO:0005604""(basement membrane)|go:""GO:0005634""(nucleus)|go:""GO:0005737""(cytoplasm)|go:""GO:0005783""(endoplasmic reticulum)|go:""GO:0005789""(endoplasmic reticulum membrane)|go:""GO:0005794""(Golgi apparatus)|go:""GO:0005829""(cytosol)|go:""GO:0005874""(microtubule)|go:""GO:0005886""(plasma membrane)|go:""GO:0005902""(microvillus)|go:""GO:0005911""(cell-cell junction)|go:""GO:0005923""(bicellular tight junction)|go:""GO:0007015""(actin filament organization)|go:""GO:0007155""(cell adhesion)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0007399""(nervous system development)|go:""GO:0008104""(protein localization)|go:""GO:0008283""(cell population proliferation)|go:""GO:0008284""(positive regulation of cell population proliferation)|go:""GO:0008360""(regulation of cell shape)|go:""GO:0009898""(cytoplasmic side of plasma membrane)|go:""GO:0009925""(basal plasma membrane)|go:""GO:0010628""(positive regulation of gene expression)|go:""GO:0010669""(epithelial structure maintenance)|go:""GO:0014069""(postsynaptic density)|go:""GO:0015459""(potassium channel regulator activity)|go:""GO:0016323""(basolateral plasma membrane)|go:""GO:0016324""(apical plasma membrane)|go:""GO:0016328""(lateral plasma membrane)|go:""GO:0019894""(kinesin binding)|go:""GO:0019900""(kinase binding)|go:""GO:0019901""(protein kinase binding)|go:""GO:0019902""(phosphatase binding)|go:""GO:0021987""(cerebral cortex development)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030054""(cell junction)|go:""GO:0030165""(PDZ domain binding)|go:""GO:0030315""(T-tubule)|go:""GO:0030425""(dendrite)|go:""GO:0030432""(peristalsis)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0030838""(positive regulation of actin filament polymerization)|go:""GO:0030866""(cortical actin cytoskeleton organization)|go:""GO:0030953""(astral microtubule organization)|go:""GO:0031253""(cell projection membrane)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0031579""(membrane raft organization)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0031641""(regulation of myelination)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0033268""(node of Ranvier)|go:""GO:0033270""(paranode region of axon)|go:""GO:0035255""(ionotropic glutamate receptor binding)|go:""GO:0035418""(protein localization to synapse)|go:""GO:0035748""(myelin sheath abaxonal region)|go:""GO:0042098""(T cell proliferation)|go:""GO:0042110""(T cell activation)|go:""GO:0042130""(negative regulation of T cell proliferation)|go:""GO:0042391""(regulation of membrane potential)|go:""GO:0042734""(presynaptic membrane)|go:""GO:0042982""(amyloid precursor protein metabolic process)|go:""GO:0043005""(neuron projection)|go:""GO:0043025""(neuronal cell body)|go:""GO:0043113""(receptor clustering)|go:""GO:0043219""(lateral loop)|go:""GO:0043268""(positive regulation of potassium ion transport)|go:""GO:0043491""(phosphatidylinositol 3-kinase/protein kinase B signal transduction)|go:""GO:0043622""(cortical microtubule organization)|go:""GO:0044325""(transmembrane transporter binding)|go:""GO:0045121""(membrane raft)|go:""GO:0045197""(establishment or maintenance of epithelial cell apical/basal polarity)|go:""GO:0045202""(synapse)|go:""GO:0045211""(postsynaptic membrane)|go:""GO:0048471""(perinuclear region of cytoplasm)|go:""GO:0048608""(reproductive structure development)|go:""GO:0048704""(embryonic skeletal system morphogenesis)|go:""GO:0048729""(tissue morphogenesis)|go:""GO:0048745""(smooth muscle tissue development)|go:""GO:0050680""(negative regulation of epithelial cell proliferation)|go:""GO:0051660""(establishment of centrosome localization)|go:""GO:0051898""(negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction)|go:""GO:0060022""(hard palate development)|go:""GO:0060090""(molecular adaptor activity)|go:""GO:0070373""(negative regulation of ERK1 and ERK2 cascade)|go:""GO:0070830""(bicellular tight junction assembly)|go:""GO:0072659""(protein localization to plasma membrane)|go:""GO:0097016""(L27 domain binding)|go:""GO:0097025""(MPP7-DLG1-LIN7 complex)|go:""GO:0097060""(synaptic membrane)|go:""GO:0097120""(receptor localization to synapse)|go:""GO:0098609""(cell-cell adhesion)|go:""GO:0098839""(postsynaptic density membrane)|go:""GO:0098911""(regulation of ventricular cardiac muscle cell action potential)|go:""GO:0098919""(structural constituent of postsynaptic density)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099072""(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:""GO:0099092""(postsynaptic density, intracellular component)|go:""GO:0099645""(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:""GO:1902473""(regulation of protein localization to synapse)|go:""GO:1903078""(positive regulation of protein localization to plasma membrane)|go:""GO:1903286""(regulation of potassium ion import)|go:""GO:1903753""(negative regulation of p38MAPK cascade)|go:""GO:1903764""(regulation of potassium ion export across plasma membrane)|go:""GO:1990416""(cellular response to brain-derived neurotrophic factor stimulus)|go:""GO:2000134""(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313(""Membrane-associated guanylate kinase (MAGUK) scaffold protein"")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|interpro:IPR050614|rcsb pdb:1RSO|rcsb pdb:1ZOK|rcsb pdb:2AWU|rcsb pdb:2AWW|rcsb pdb:2AWX|rcsb pdb:2G2L|rcsb pdb:2I0I|rcsb pdb:2I0L|rcsb pdb:3UAT|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5673001|reactome:R-RNO-8849932|mint:Q62696|dip:DIP-31527N|panther:PTHR23119(orthology-group)"	-	-	-	figure legend:fig. 1b,1c table 2|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/13	2024/11/14	rogid:9JzwwZQrNraeZGU9Yv2lBn78En8574521	rogid:ThHAJAsBhWNjz4P6frniUm2xaJI10116	intact-crc:CB9E84C99C15417F|rigid:PHx3oQUpUgx6yhlV+meIPESMr88	false	binding-associated region:391-440|glutathione s tranferase tag:?-?	binding-associated region:459-607|his tag:?-?	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0707""(anti tag immunostaining)"
uniprotkb:B7UR60	uniprotkb:Q62936	intact:EBI-25435618	intact:EBI-349596|uniprotkb:P70547|ensembl:ENSRNOP00000003741.2	psi-mi:b7ur60_eco27(display_long)|uniprotkb:E2348C_1442(locus name)	psi-mi:dlg3_rat(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)|uniprotkb:PSD-95/SAP90-related protein 1(gene name synonym)	"psi-mi:""MI:0089""(protein array)"	Lee et al. (2008)	pubmed:17979986|imex:IM-28455	"taxid:574521(eco27)|taxid:574521(""Escherichia coli O127:H6 (strain E2348/69 / EPEC)"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-26429889|imex:IM-28455-19	intact-miscore:0.44	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	mint:B7UR60|refseq:WP_001025663.1	"rgd:68423|refseq:NP_113827.1|ensembl:ENSRNOG00000002767.9(gene)|ensembl:ENSRNOT00000003741.7(transcript)|go:""GO:0001736""(establishment of planar polarity)|go:""GO:0005737""(cytoplasm)|go:""GO:0005886""(plasma membrane)|go:""GO:0005911""(cell-cell junction)|go:""GO:0005923""(bicellular tight junction)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0007399""(nervous system development)|go:""GO:0014069""(postsynaptic density)|go:""GO:0016323""(basolateral plasma membrane)|go:""GO:0019900""(kinase binding)|go:""GO:0019901""(protein kinase binding)|go:""GO:0019902""(phosphatase binding)|go:""GO:0019903""(protein phosphatase binding)|go:""GO:0019904""(protein domain specific binding)|go:""GO:0030165""(PDZ domain binding)|go:""GO:0030426""(growth cone)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0031625""(ubiquitin protein ligase binding)|go:""GO:0032281""(AMPA glutamate receptor complex)|go:""GO:0035255""(ionotropic glutamate receptor binding)|go:""GO:0035418""(protein localization to synapse)|go:""GO:0043005""(neuron projection)|go:""GO:0043025""(neuronal cell body)|go:""GO:0043113""(receptor clustering)|go:""GO:0043198""(dendritic shaft)|go:""GO:0045197""(establishment or maintenance of epithelial cell apical/basal polarity)|go:""GO:0045202""(synapse)|go:""GO:0097120""(receptor localization to synapse)|go:""GO:0098609""(cell-cell adhesion)|go:""GO:0098839""(postsynaptic density membrane)|go:""GO:0098919""(structural constituent of postsynaptic density)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099072""(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:""GO:0099092""(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313(""Membrane-associated guanylate kinase (MAGUK) scaffold protein"")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|interpro:IPR050614|mint:Q62936|rcsb pdb:3JXT|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5673001|reactome:R-RNO-6794361|reactome:R-RNO-8849932|refseq:XP_006257144.1|panther:PTHR23119(orthology-group)"	-	-	-	figure legend:fig. 1b,1c table 2|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/13	2024/11/14	rogid:9JzwwZQrNraeZGU9Yv2lBn78En8574521	rogid:SE5z/dJFoJsSa0HYyz7KOlFDHio10116	intact-crc:259EBF12292BC839|rigid:U7yxDCgQSQG5zyYqFsKwpK23NsA	false	binding-associated region:391-440|glutathione s tranferase tag:?-?	binding-associated region:398-552|his tag:?-?	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0707""(anti tag immunostaining)"
uniprotkb:Q2GL86	uniprotkb:P04785	intact:EBI-26435798	intact:EBI-915861|uniprotkb:P13700|ensembl:ENSRNOP00000051841.1	psi-mi:q2gl86_anapz(display_long)|uniprotkb:APH_0248(locus name)	psi-mi:pdia1_rat(display_long)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:P4hb(gene name)|psi-mi:P4hb(display_short)|uniprotkb:Pdia1(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Green et al. (2020)	pubmed:31992623|imex:IM-28466	"taxid:212042(anapz)|taxid:212042(""Anaplasma phagocytophilum (strain HZ)"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-26435952|imex:IM-28466-15	intact-miscore:0.40	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	refseq:WP_011450388.1|mint:Q2GL86	"rgd:3244|ensembl:ENSRNOG00000036689.3(gene)|ensembl:ENSRNOT00000054958.3(transcript)|go:""GO:0003756""(protein disulfide isomerase activity)|go:""GO:0003779""(actin binding)|go:""GO:0004656""(procollagen-proline 4-dioxygenase activity)|go:""GO:0005178""(integrin binding)|go:""GO:0005783""(endoplasmic reticulum)|go:""GO:0005788""(endoplasmic reticulum lumen)|go:""GO:0005793""(endoplasmic reticulum-Golgi intermediate compartment)|go:""GO:0005829""(cytosol)|go:""GO:0005856""(cytoskeleton)|go:""GO:0006457""(protein folding)|go:""GO:0006888""(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:""GO:0009897""(external side of plasma membrane)|go:""GO:0015035""(protein-disulfide reductase activity)|go:""GO:0016222""(procollagen-proline 4-dioxygenase complex)|go:""GO:0016972""(thiol oxidase activity)|go:""GO:0019899""(enzyme binding)|go:""GO:0030027""(lamellipodium)|go:""GO:0030070""(insulin processing)|go:""GO:0032991""(protein-containing complex)|go:""GO:0034663""(endoplasmic reticulum chaperone complex)|go:""GO:0034975""(protein folding in endoplasmic reticulum)|go:""GO:0034976""(response to endoplasmic reticulum stress)|go:""GO:0042470""(melanosome)|go:""GO:0044877""(protein-containing complex binding)|go:""GO:0045785""(positive regulation of cell adhesion)|go:""GO:0046598""(positive regulation of viral entry into host cell)|go:""GO:0046982""(protein heterodimerization activity)|go:""GO:0071456""(cellular response to hypoxia)|go:""GO:0098761""(cellular response to interleukin-7)|go:""GO:1900026""(positive regulation of substrate adhesion-dependent cell spreading)|go:""GO:1902175""(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P04785|reactome:R-RNO-1650814|reactome:R-RNO-264876|reactome:R-RNO-3299685|reactome:R-RNO-381426|reactome:R-RNO-5358346|reactome:R-RNO-8866423|reactome:R-RNO-8957275|reactome:R-RNO-8963888|reactome:R-RNO-8964041|reactome:R-RNO-9020591|reactome:R-RNO-9020933|refseq:NP_037130.2|panther:PTHR18929(orthology-group)"	-	-	-	figure legend:f1b|comment:His-PDI-coupled nickel resin or nickel resin alone was incubated with A. phagocytophilum DC bacteria that had been recovered after sonication of infected HL-60 cells.|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:948(anaph)|taxid:948(Anaplasma phagocytophilum)	-	2020/10/30	2024/11/14	rogid:5GJtPfOT8FV2sm0NkPlURGCY7Ok212042	rogid:nXaUDIKzWIRQ95lFxT0hB0T9enQ10116	intact-crc:37E7567EE9B97A82|rigid:X2NRSTH3EnH0Ycis91bpkipiHxM	false	-	his tag:?-?	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:P10844	uniprotkb:P29101	intact:EBI-7661991|uniprotkb:P10843|intact:MINT-1795550	intact:EBI-458017	psi-mi:bxb_clobo(display_long)|uniprotkb:botB(gene name)|psi-mi:botB(display_short)|uniprotkb:Bontoxilysin-B(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Strotmeier et al. (2012)	pubmed:22265973|imex:IM-16810|mint:MINT-8302006	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-7661986|mint:MINT-8302011|imex:IM-16810-1	intact-miscore:0.77	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:WP_012291519.1|dip:DIP-42782N|mint:P10844|rcsb pdb:1F31|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1EPW|rcsb pdb:1F82|rcsb pdb:1G9A|rcsb pdb:1G9B|rcsb pdb:1G9C|rcsb pdb:1G9D|rcsb pdb:1I1E|rcsb pdb:1S0B|rcsb pdb:1S0C|rcsb pdb:1S0D|rcsb pdb:1S0E|rcsb pdb:1S0F|rcsb pdb:1S0G|rcsb pdb:1Z0H|rcsb pdb:2ETF|rcsb pdb:2NM1|rcsb pdb:2NP0|rcsb pdb:2XHL|rcsb pdb:3ZUQ|rcsb pdb:4KBB|rcsb pdb:5VID|rcsb pdb:5VMR|rcsb pdb:6G5F|rcsb pdb:6G5G|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6UC6|rcsb pdb:6UFT|rcsb pdb:6UHT|rcsb pdb:6UL4|rcsb pdb:7NA9|rcsb pdb:7QFQ|rcsb pdb:7T5F|reactome:R-HSA-5250958|mint:MINT-8302013(identity)"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)|mint:MINT-8302014(identity)"	-	"comment:mint|function:""\""Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2\"""""	-	figure legend:f2|comment:mint|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/03	2024/11/14	rogid:TyP1/JJzdgNBsIqolX4P5Vc+9Ag1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:027DB451235CC88F|rigid:5VTvp7jz8LSWDObE8OcmI6JyJJQ	false	polyprotein fragment:442-1291(MINT-8302017)	binding-associated region:1-61(MINT-8302023)|mutation disrupting interaction:54-54(MINT-8302026)|glutathione s tranferase tag:?-?(MINT-8302020)	-	-	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"
uniprotkb:P10844	uniprotkb:P29101	intact:EBI-7661991|uniprotkb:P10843|intact:MINT-1795550	intact:EBI-458017	psi-mi:bxb_clobo(display_long)|uniprotkb:botB(gene name)|psi-mi:botB(display_short)|uniprotkb:Bontoxilysin-B(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Strotmeier et al. (2012)	pubmed:22265973|imex:IM-16810|mint:MINT-8302006	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-7662113|mint:MINT-8302030|imex:IM-16810-2	intact-miscore:0.77	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:WP_012291519.1|dip:DIP-42782N|mint:P10844|rcsb pdb:1F31|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1EPW|rcsb pdb:1F82|rcsb pdb:1G9A|rcsb pdb:1G9B|rcsb pdb:1G9C|rcsb pdb:1G9D|rcsb pdb:1I1E|rcsb pdb:1S0B|rcsb pdb:1S0C|rcsb pdb:1S0D|rcsb pdb:1S0E|rcsb pdb:1S0F|rcsb pdb:1S0G|rcsb pdb:1Z0H|rcsb pdb:2ETF|rcsb pdb:2NM1|rcsb pdb:2NP0|rcsb pdb:2XHL|rcsb pdb:3ZUQ|rcsb pdb:4KBB|rcsb pdb:5VID|rcsb pdb:5VMR|rcsb pdb:6G5F|rcsb pdb:6G5G|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6UC6|rcsb pdb:6UFT|rcsb pdb:6UHT|rcsb pdb:6UL4|rcsb pdb:7NA9|rcsb pdb:7QFQ|rcsb pdb:7T5F|reactome:R-HSA-5250958|mint:MINT-8302032(identity)"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)|mint:MINT-8302036(identity)"	-	"comment:mint|function:""\""Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2\"""""	-	figure legend:f2|comment:mint|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/03	2024/11/14	rogid:TyP1/JJzdgNBsIqolX4P5Vc+9Ag1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:D5C7895127E27A31|rigid:5VTvp7jz8LSWDObE8OcmI6JyJJQ	false	polyprotein fragment:442-1291(MINT-8302033)	binding-associated region:1-61(MINT-8302039)|mutation disrupting interaction:54-54(MINT-8302037)|glutathione s tranferase tag:?-?(MINT-8302041)	-	-	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"
uniprotkb:Q60393	uniprotkb:P29101	intact:EBI-7662172|intact:MINT-8302082	intact:EBI-458017	psi-mi:bxg_clobo(display_long)|uniprotkb:botG(gene name)|psi-mi:botG(display_short)|uniprotkb:Bontoxilysin-G(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Strotmeier et al. (2012)	pubmed:22265973|imex:IM-16810|mint:MINT-8302006	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-7662167|mint:MINT-8302047|imex:IM-16810-3	intact-miscore:0.44	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"dip:DIP-60790N|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1ZB7|rcsb pdb:2VXR|rcsb pdb:3MPP|reactome:R-HSA-5250989|mint:Q60393|mint:MINT-8302049(identity)"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)|mint:MINT-8302053(identity)"	-	comment:mint	-	figure legend:f2|comment:mint|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/03	2024/11/14	rogid:iiQDCLuEVr+FIbb5ldtastiXXXc1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:9B1F42672A7FC3BF|rigid:bzl/AUNJxVSb8jJO9XunSbHJgxI	false	polyprotein fragment:443-1297(MINT-8302050)	glutathione s tranferase tag:?-?(MINT-8302054)|mutation disrupting interaction:54-54(MINT-8302058)|binding-associated region:1-61(MINT-8302056)	-	-	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"
uniprotkb:P0ABE7	uniprotkb:P54311	intact:EBI-1120486|uniprotkb:P00192|uniprotkb:P76805|uniprotkb:Q8XCE3	intact:EBI-917779|uniprotkb:Q6Q8B1|uniprotkb:Q9QWG8|ensembl:ENSRNOP00000044340.2	psi-mi:c562_ecolx(display_long)|uniprotkb:cybC(gene name)|psi-mi:cybC(display_short)	psi-mi:gbb1_rat(display_long)|uniprotkb:Transducin beta chain 1(gene name synonym)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short)	"psi-mi:""MI:0410""(3D electron microscopy)"	Kang et al. (2018)	pubmed:29899450|imex:IM-28379	taxid:562(ecolx)|taxid:562(Escherichia coli)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-25681738|wwpdb:6CMO|emdb:EMD-7517|imex:IM-28379-1	intact-miscore:0.49	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"rcsb pdb:3M4C|rcsb pdb:3M79|rcsb pdb:3NMI|rcsb pdb:3NMJ|rcsb pdb:3NMK|rcsb pdb:3TOL|rcsb pdb:3TOM|rcsb pdb:8K2W|rcsb pdb:8HNK|rcsb pdb:8HNL|rcsb pdb:8HNM|rcsb pdb:8HNN|rcsb pdb:8JLJ|rcsb pdb:8JLK|rcsb pdb:8JLN|rcsb pdb:8JLO|rcsb pdb:8JLP|rcsb pdb:8JLQ|rcsb pdb:8JLR|rcsb pdb:8JSO|rcsb pdb:7XWO|rcsb pdb:8C9W|rcsb pdb:8CIC|rcsb pdb:8HJ5|rcsb pdb:8IRS|rcsb pdb:8IRT|rcsb pdb:8IRV|rcsb pdb:8K2X|rcsb pdb:8PWN|rcsb pdb:8W8B|rcsb pdb:8A2O|rcsb pdb:8A2P|rcsb pdb:8HQE|rcsb pdb:8HQM|rcsb pdb:8HQN|rcsb pdb:8HVI|rcsb pdb:8IHB|rcsb pdb:8IHF|rcsb pdb:8IHH|rcsb pdb:8IHI|rcsb pdb:8IHJ|rcsb pdb:8IHK|rcsb pdb:8J7E|rcsb pdb:8JJ8|rcsb pdb:8JJL|rcsb pdb:8JMT|rcsb pdb:8TB7|rcsb pdb:8DRE|rcsb pdb:7SQ0|rcsb pdb:7T2G|rcsb pdb:7XKI|rcsb pdb:7XKT|rcsb pdb:8DR8|rcsb pdb:8DRA|rcsb pdb:8DRK|rcsb pdb:8DRN|rcsb pdb:8DRO|rcsb pdb:8DRQ|rcsb pdb:8DS3|rcsb pdb:8DS9|rcsb pdb:8DSA|rcsb pdb:8F74|rcsb pdb:8F77|rcsb pdb:8F79|rcsb pdb:8F7B|rcsb pdb:8F7D|rcsb pdb:8F7E|rcsb pdb:8F7J|rcsb pdb:8FYN|rcsb pdb:8GNE|rcsb pdb:8GY7|rcsb pdb:8HII|rcsb pdb:8HIJ|rcsb pdb:8HIK|rcsb pdb:8HS2|rcsb pdb:8HS3|rcsb pdb:8HSC|rcsb pdb:7F61|rcsb pdb:7PP1|rcsb pdb:7TX7|rcsb pdb:7W53|rcsb pdb:7W55|rcsb pdb:7W56|rcsb pdb:7W57|rcsb pdb:7X5H|rcsb pdb:8DEP|rcsb pdb:8DRD|rcsb pdb:8DRF|rcsb pdb:8DRJ|rcsb pdb:8DRL|rcsb pdb:8DRM|rcsb pdb:7TX6|rcsb pdb:7MK4|rcsb pdb:7N4F|rcsb pdb:7N4G|rcsb pdb:7XTC|rcsb pdb:7XZ5|rcsb pdb:7XZ6|rcsb pdb:7Y12|rcsb pdb:7Y13|rcsb pdb:7Y14|rcsb pdb:7Y15|rcsb pdb:7YXA|rcsb pdb:7ZI0|rcsb pdb:8CU6|rcsb pdb:8CU7|rcsb pdb:8DEN|rcsb pdb:8DJK|rcsb pdb:8DJM|rcsb pdb:8DU3|rcsb pdb:4IAQ|rcsb pdb:7RWW|rcsb pdb:7RWX|rcsb pdb:7RWY|rcsb pdb:7SBF|rcsb pdb:7SU2|rcsb pdb:7T32|rcsb pdb:7TEP|rcsb pdb:7W0L|rcsb pdb:7W0M|rcsb pdb:7W0N|rcsb pdb:7W0O|rcsb pdb:7W0P|rcsb pdb:7WC6|rcsb pdb:7WC7|rcsb pdb:7WC8|rcsb pdb:7WC9|rcsb pdb:7WJ5|rcsb pdb:7XAY|rcsb pdb:7XT8|rcsb pdb:7XT9|rcsb pdb:7XTA|rcsb pdb:7RWV|rcsb pdb:7XTB|rcsb pdb:3U8P|rcsb pdb:7RWU|rcsb pdb:4PXZ|rcsb pdb:4PY0|rcsb pdb:5DHG|rcsb pdb:8I7V|rcsb pdb:8I7W|rcsb pdb:8JPN|rcsb pdb:8JPP|rcsb pdb:8K9K|rcsb pdb:8RLN|rcsb pdb:8TH3|rcsb pdb:8TH4|rcsb pdb:8YRG|rcsb pdb:4RWA|rcsb pdb:4RWD|rcsb pdb:4U9D|rcsb pdb:4L6R|rcsb pdb:4N6H|rcsb pdb:4NC3|interpro:IPR009155(Cytochrome b562)|interpro:IPR010980(Cytochrome c and b562)|rcsb pdb:1APC|rcsb pdb:1LM3|rcsb pdb:1M6T|rcsb pdb:1QPU|rcsb pdb:1QQ3|rcsb pdb:256B|rcsb pdb:2BC5|rcsb pdb:2QLA|rcsb pdb:3C62|rcsb pdb:3C63|rcsb pdb:3DE8|rcsb pdb:3DE9|rcsb pdb:3FOO|rcsb pdb:3FOP|rcsb pdb:3HNI|rcsb pdb:3HNJ|rcsb pdb:3HNK|rcsb pdb:3HNL|rcsb pdb:3IQ5|rcsb pdb:3IQ6|rcsb pdb:3L1M|rcsb pdb:3M15|rcsb pdb:3M4B|rcsb pdb:6BQG|rcsb pdb:6BQH|rcsb pdb:5YO3|rcsb pdb:7EZC|rcsb pdb:7F4D|rcsb pdb:7F4F|rcsb pdb:7F4H|rcsb pdb:7F4I|rcsb pdb:7JNI|rcsb pdb:7LR5|rcsb pdb:7LRA|rcsb pdb:7LRB|rcsb pdb:7LRR|rcsb pdb:7LRV|rcsb pdb:7LSJ|rcsb pdb:7LSL|rcsb pdb:7LSN|rcsb pdb:7LV1|rcsb pdb:7LV4|rcsb pdb:7PX4|rcsb pdb:7PYR|rcsb pdb:7WVV|rcsb pdb:7WVW|rcsb pdb:7WVX|rcsb pdb:7WVY|rcsb pdb:6DY4|rcsb pdb:6DY6|rcsb pdb:6DY8|rcsb pdb:6DYB|rcsb pdb:6DYC|rcsb pdb:6DYD|rcsb pdb:6DYE|rcsb pdb:6DYF|rcsb pdb:6DYG|rcsb pdb:6DYH|rcsb pdb:6DYI|rcsb pdb:6DYJ|rcsb pdb:6DYK|rcsb pdb:6DYL|rcsb pdb:6M97|rcsb pdb:6M98|rcsb pdb:5UEN|rcsb pdb:4EIY|rcsb pdb:4IAR|rcsb pdb:4IB4|rcsb pdb:4JE9|rcsb pdb:4JEA|rcsb pdb:4JEB|rcsb pdb:4EA3|rcsb pdb:7F83|rcsb pdb:7F9Y|rcsb pdb:7F9Z|rcsb pdb:7S8M|rcsb pdb:7S8O|rcsb pdb:7S8P|rcsb pdb:7VOD|rcsb pdb:7VOE|rcsb pdb:4JKV|rcsb pdb:6S0Q|rcsb pdb:5WIU|rcsb pdb:5WIV|rcsb pdb:6LW5|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|rcsb pdb:6OT4|rcsb pdb:6OT7|rcsb pdb:6OT8|rcsb pdb:6OT9|rcsb pdb:6OVH|rcsb pdb:4O9R|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5L7D|rcsb pdb:5L7I|rcsb pdb:7ARO|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7KOO|rcsb pdb:7KOQ|rcsb pdb:7KOX|rcsb pdb:4NTJ|rcsb pdb:4OR2|rcsb pdb:6DO1|rcsb pdb:6CC4|rcsb pdb:6CMO|rcsb pdb:5BU7|rcsb pdb:4U9E|refseq:WP_001232240.1|rcsb pdb:6GT3|rcsb pdb:5YO4|rcsb pdb:5YO5|rcsb pdb:5YO6|rcsb pdb:4QIM|rcsb pdb:4QIN|rcsb pdb:6AK3|rcsb pdb:6G7O|rcsb pdb:6IIU|rcsb pdb:6IIV|rcsb pdb:4YAY|rcsb pdb:4Z34|rcsb pdb:4Z35|rcsb pdb:4Z36|rcsb pdb:4ZUD|rcsb pdb:5AWI|rcsb pdb:6ME6|rcsb pdb:6ME7|rcsb pdb:6ME8|rcsb pdb:6ME9|rcsb pdb:6MH8|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6WQA|rcsb pdb:7DFP|rcsb pdb:7JVR|rcsb pdb:8JT6|rcsb pdb:8FDO|rcsb pdb:8H2G|rcsb pdb:8JT8|rcsb pdb:8RQQ|rcsb pdb:8WRZ|rcsb pdb:8X2K|rcsb pdb:8XV2|rcsb pdb:8XV5|rcsb pdb:8XV9|rcsb pdb:6C1Q|rcsb pdb:6C1R|rcsb pdb:6D32|rcsb pdb:6D35|go:""GO:0005506""(iron ion binding)|go:""GO:0009055""(electron transfer activity)|go:""GO:0020037""(heme binding)|go:""GO:0022900""(electron transport chain)|go:""GO:0042597""(periplasmic space)|rcsb pdb:8FY8|rcsb pdb:8FYE|rcsb pdb:8FYL|rcsb pdb:8FYT|rcsb pdb:8FYX|rcsb pdb:8K9L|rcsb pdb:8TS1|rcsb pdb:8TS2|rcsb pdb:8TS3|rcsb pdb:8XVJ|rcsb pdb:8XVK|rcsb pdb:8XVL|rcsb pdb:8YZK|rcsb pdb:8ZFJ|rcsb pdb:8ZFK|rcsb pdb:8ZFL|rcsb pdb:8ZFM|rcsb pdb:8ZMF|rcsb pdb:8ZMG|rcsb pdb:8ZSJ|rcsb pdb:8ZSP|rcsb pdb:8ZSS|rcsb pdb:8ZSV|rcsb pdb:6UR8|rcsb pdb:6USF|rcsb pdb:5JTB|rcsb pdb:5UVI|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5L31|rcsb pdb:5L32|rcsb pdb:5TVN|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:5VRA|rcsb pdb:5XZI|rcsb pdb:5XZJ|rcsb pdb:6AQF|rcsb pdb:6B73|rcsb pdb:5UIG|rcsb pdb:5UNF|rcsb pdb:5UNG|rcsb pdb:5UNH|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|rcsb pdb:7EXD|rcsb pdb:7MYZ|rcsb pdb:7RM5|rcsb pdb:5DHH|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5N2S|rcsb pdb:5TUD|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5YM7|rcsb pdb:5XJM|rcsb pdb:6DHY|rcsb pdb:6DHZ|rcsb pdb:6DRX|rcsb pdb:6DRY|rcsb pdb:6DRZ|rcsb pdb:6DS0|rcsb pdb:7XRZ|rcsb pdb:7XY6|rcsb pdb:7XY7|rcsb pdb:7YIT|rcsb pdb:7ZL9|rcsb pdb:7ZLY|rcsb pdb:8F7C|rcsb pdb:8IBU|rcsb pdb:8IBV|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6CBV|rcsb pdb:6AI5|rcsb pdb:6JZH|rcsb pdb:6PS7|rcsb pdb:6RZ4|rcsb pdb:6RZ5|rcsb pdb:6IQL|rcsb pdb:6JOD|rcsb pdb:6RZ6|rcsb pdb:6RZ7|rcsb pdb:6RZ8|rcsb pdb:6RZ9|rcsb pdb:6KO5|rcsb pdb:6WW2|rcsb pdb:6WWZ|rcsb pdb:7BW0|rcsb pdb:7C61|rcsb pdb:7C6A|rcsb pdb:6WHA|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WYU|rcsb pdb:6WZ0|rcsb pdb:6WZ1|rcsb pdb:6WZ2|rcsb pdb:6WZ3|rcsb pdb:6WZ7|rcsb pdb:6WZA|rcsb pdb:6WZC|rcsb pdb:6X7E|rcsb pdb:6X8X|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:8HN8|rcsb pdb:8HOC|rcsb pdb:8IKJ|rcsb pdb:8J9O|rcsb pdb:8JH7|rcsb pdb:8JHC|rcsb pdb:8K8J|rcsb pdb:8UHB|rcsb pdb:8UT1|rcsb pdb:8UTB|rcsb pdb:8UZJ|rcsb pdb:8V80|rcsb pdb:8V82|rcsb pdb:8V86|rcsb pdb:8V88|rcsb pdb:8V89|rcsb pdb:8V8A|rcsb pdb:8V8C|rcsb pdb:8V8D|rcsb pdb:8W8Q|rcsb pdb:8X5X"	"rgd:2718|refseq:NP_112249.2|refseq:XP_006239579.1|refseq:XP_008762557.1|refseq:XP_017448634.1|refseq:XP_017448635.1|refseq:XP_017448636.1|refseq:XP_017448637.1|refseq:XP_017448638.1|dip:DIP-37029N|ensembl:ENSRNOG00000016638.6(gene)|ensembl:ENSRNOT00000041789.3(transcript)|go:""GO:0001750""(photoreceptor outer segment)|go:""GO:0001917""(photoreceptor inner segment)|go:""GO:0003924""(GTPase activity)|go:""GO:0005737""(cytoplasm)|go:""GO:0005834""(heterotrimeric G-protein complex)|go:""GO:0005886""(plasma membrane)|go:""GO:0007186""(G protein-coupled receptor signaling pathway)|go:""GO:0007200""(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:""GO:0007204""(positive regulation of cytosolic calcium ion concentration)|go:""GO:0008283""(cell population proliferation)|go:""GO:0010659""(cardiac muscle cell apoptotic process)|go:""GO:0030159""(signaling receptor complex adaptor activity)|go:""GO:0030425""(dendrite)|go:""GO:0030507""(spectrin binding)|go:""GO:0042622""(photoreceptor outer segment membrane)|go:""GO:0044297""(cell body)|go:""GO:0044877""(protein-containing complex binding)|go:""GO:0045202""(synapse)|go:""GO:0047391""(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:""GO:0050909""(sensory perception of taste)|go:""GO:0051020""(GTPase binding)|go:""GO:0060041""(retina development in camera-type eye)|go:""GO:0071456""(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P54311|rcsb pdb:3SN6|rcsb pdb:5TDH|rcsb pdb:5VAI|rcsb pdb:6CMO|rcsb pdb:6LPB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6WWZ|rcsb pdb:7BW0|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7DH5|rcsb pdb:7DTY|rcsb pdb:7DUQ|rcsb pdb:7DUR|rcsb pdb:7DW9|rcsb pdb:7EIB|rcsb pdb:7EQ1|rcsb pdb:7EVM|rcsb pdb:7F16|rcsb pdb:7F2O|rcsb pdb:7FIG|rcsb pdb:7FIH|rcsb pdb:7FII|rcsb pdb:7FIM|rcsb pdb:7FIN|rcsb pdb:7FIY|rcsb pdb:7LJC|rcsb pdb:7LJD|rcsb pdb:7MBX|rcsb pdb:7MBY|rcsb pdb:7PIU|rcsb pdb:7PIV|rcsb pdb:7T6S|rcsb pdb:7T6T|rcsb pdb:7T6U|rcsb pdb:7T6V|rcsb pdb:7TRY|rcsb pdb:7TS0|rcsb pdb:7V35|rcsb pdb:7V9L|rcsb pdb:7V9M|rcsb pdb:7VAB|rcsb pdb:7VBH|rcsb pdb:7VBI|rcsb pdb:7VGY|rcsb pdb:7VGZ|rcsb pdb:7VH0|rcsb pdb:7VQX|rcsb pdb:7VVJ|rcsb pdb:7VVK|rcsb pdb:7VVL|rcsb pdb:7VVM|rcsb pdb:7VVN|rcsb pdb:7VVO|rcsb pdb:7WBJ|rcsb pdb:7WIC|rcsb pdb:7WIG|rcsb pdb:7WQ3|rcsb pdb:7WQ4|rcsb pdb:7X8R|rcsb pdb:7X8S|rcsb pdb:7XJH|rcsb pdb:7XJI|rcsb pdb:7XW9|rcsb pdb:7XWO|rcsb pdb:7Y35|rcsb pdb:7Y36|rcsb pdb:7YU3|rcsb pdb:7YU5|rcsb pdb:7YU6|rcsb pdb:7YU7|rcsb pdb:7YU8|rcsb pdb:8EF5|rcsb pdb:8EF6|rcsb pdb:8EFB|rcsb pdb:8EFL|rcsb pdb:8EFO|rcsb pdb:8EFQ|rcsb pdb:8F7Q|rcsb pdb:8F7R|rcsb pdb:8F7S|rcsb pdb:8F7W|rcsb pdb:8F7X|rcsb pdb:8GW8|rcsb pdb:8HA0|rcsb pdb:8HAF|rcsb pdb:8HAO|rcsb pdb:8HK2|rcsb pdb:8HK3|rcsb pdb:8HK5|rcsb pdb:8ITL|rcsb pdb:8ITM|rcsb pdb:8IY5|rcsb pdb:8JBF|rcsb pdb:8JBG|rcsb pdb:8JBH|rcsb pdb:8JIP|rcsb pdb:8JIQ|rcsb pdb:8JIR|rcsb pdb:8JIS|rcsb pdb:8JIT|rcsb pdb:8JIU|rcsb pdb:8WA3|rcsb pdb:8WG7|rcsb pdb:8WG8|rcsb pdb:8WZ2|rcsb pdb:8X16|rcsb pdb:8X17|rcsb pdb:8XBE|rcsb pdb:8XBH|rcsb pdb:8XGR|rcsb pdb:8XOR|rcsb pdb:8XOS|rcsb pdb:8YKV|rcsb pdb:8YKW|rcsb pdb:8YKX|rcsb pdb:8ZBE|rcsb pdb:8ZCJ|rcsb pdb:8ZH8|rcsb pdb:9F33|rcsb pdb:9F34|rcsb pdb:9IJD|rcsb pdb:9IJE|rcsb pdb:9JR2|rcsb pdb:9JR3|reactome:R-RNO-1296041|reactome:R-RNO-202040|reactome:R-RNO-2485179|reactome:R-RNO-381676|reactome:R-RNO-392170|reactome:R-RNO-392451|reactome:R-RNO-400042|reactome:R-RNO-4086398|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-418597|reactome:R-RNO-420092|reactome:R-RNO-428930|reactome:R-RNO-432040|reactome:R-RNO-456926|reactome:R-RNO-6814122|reactome:R-RNO-8964616|reactome:R-RNO-9717207|reactome:R-RNO-9856530|reactome:R-RNO-997272|panther:PTHR19850(orthology-group)"	-	-	-	figure legend:Fig 2, Extended Data Fig 2, Extended Data Table 1|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/17	2024/11/14	rogid:O9HPXjm/UQpqt+WPfwjDOEx8+m4562	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10116	intact-crc:6AA84C2B8C5EB848|rigid:byUWCYFrBR1Dh68SItQ8WMUKU8E	false	-	-	1	1	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:2287""(identification by structure determination)"	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:2287""(identification by structure determination)"
uniprotkb:P0ABE7	uniprotkb:P54311	intact:EBI-1120486|uniprotkb:P00192|uniprotkb:P76805|uniprotkb:Q8XCE3	intact:EBI-917779|uniprotkb:Q6Q8B1|uniprotkb:Q9QWG8|ensembl:ENSRNOP00000044340.2	psi-mi:c562_ecolx(display_long)|uniprotkb:cybC(gene name)|psi-mi:cybC(display_short)	psi-mi:gbb1_rat(display_long)|uniprotkb:Transducin beta chain 1(gene name synonym)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short)	"psi-mi:""MI:0071""(molecular sieving)"	Kang et al. (2018)	pubmed:29899450|imex:IM-28379	taxid:562(ecolx)|taxid:562(Escherichia coli)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-25681765|imex:IM-28379-3	intact-miscore:0.49	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"rcsb pdb:3M4C|rcsb pdb:3M79|rcsb pdb:3NMI|rcsb pdb:3NMJ|rcsb pdb:3NMK|rcsb pdb:3TOL|rcsb pdb:3TOM|rcsb pdb:8K2W|rcsb pdb:8HNK|rcsb pdb:8HNL|rcsb pdb:8HNM|rcsb pdb:8HNN|rcsb pdb:8JLJ|rcsb pdb:8JLK|rcsb pdb:8JLN|rcsb pdb:8JLO|rcsb pdb:8JLP|rcsb pdb:8JLQ|rcsb pdb:8JLR|rcsb pdb:8JSO|rcsb pdb:7XWO|rcsb pdb:8C9W|rcsb pdb:8CIC|rcsb pdb:8HJ5|rcsb pdb:8IRS|rcsb pdb:8IRT|rcsb pdb:8IRV|rcsb pdb:8K2X|rcsb pdb:8PWN|rcsb pdb:8W8B|rcsb pdb:8A2O|rcsb pdb:8A2P|rcsb pdb:8HQE|rcsb pdb:8HQM|rcsb pdb:8HQN|rcsb pdb:8HVI|rcsb pdb:8IHB|rcsb pdb:8IHF|rcsb pdb:8IHH|rcsb pdb:8IHI|rcsb pdb:8IHJ|rcsb pdb:8IHK|rcsb pdb:8J7E|rcsb pdb:8JJ8|rcsb pdb:8JJL|rcsb pdb:8JMT|rcsb pdb:8TB7|rcsb pdb:8DRE|rcsb pdb:7SQ0|rcsb pdb:7T2G|rcsb pdb:7XKI|rcsb pdb:7XKT|rcsb pdb:8DR8|rcsb pdb:8DRA|rcsb pdb:8DRK|rcsb pdb:8DRN|rcsb pdb:8DRO|rcsb pdb:8DRQ|rcsb pdb:8DS3|rcsb pdb:8DS9|rcsb pdb:8DSA|rcsb pdb:8F74|rcsb pdb:8F77|rcsb pdb:8F79|rcsb pdb:8F7B|rcsb pdb:8F7D|rcsb pdb:8F7E|rcsb pdb:8F7J|rcsb pdb:8FYN|rcsb pdb:8GNE|rcsb pdb:8GY7|rcsb pdb:8HII|rcsb pdb:8HIJ|rcsb pdb:8HIK|rcsb pdb:8HS2|rcsb pdb:8HS3|rcsb pdb:8HSC|rcsb pdb:7F61|rcsb pdb:7PP1|rcsb pdb:7TX7|rcsb pdb:7W53|rcsb pdb:7W55|rcsb pdb:7W56|rcsb pdb:7W57|rcsb pdb:7X5H|rcsb pdb:8DEP|rcsb pdb:8DRD|rcsb pdb:8DRF|rcsb pdb:8DRJ|rcsb pdb:8DRL|rcsb pdb:8DRM|rcsb pdb:7TX6|rcsb pdb:7MK4|rcsb pdb:7N4F|rcsb pdb:7N4G|rcsb pdb:7XTC|rcsb pdb:7XZ5|rcsb pdb:7XZ6|rcsb pdb:7Y12|rcsb pdb:7Y13|rcsb pdb:7Y14|rcsb pdb:7Y15|rcsb pdb:7YXA|rcsb pdb:7ZI0|rcsb pdb:8CU6|rcsb pdb:8CU7|rcsb pdb:8DEN|rcsb pdb:8DJK|rcsb pdb:8DJM|rcsb pdb:8DU3|rcsb pdb:4IAQ|rcsb pdb:7RWW|rcsb pdb:7RWX|rcsb pdb:7RWY|rcsb pdb:7SBF|rcsb pdb:7SU2|rcsb pdb:7T32|rcsb pdb:7TEP|rcsb pdb:7W0L|rcsb pdb:7W0M|rcsb pdb:7W0N|rcsb pdb:7W0O|rcsb pdb:7W0P|rcsb pdb:7WC6|rcsb pdb:7WC7|rcsb pdb:7WC8|rcsb pdb:7WC9|rcsb pdb:7WJ5|rcsb pdb:7XAY|rcsb pdb:7XT8|rcsb pdb:7XT9|rcsb pdb:7XTA|rcsb pdb:7RWV|rcsb pdb:7XTB|rcsb pdb:3U8P|rcsb pdb:7RWU|rcsb pdb:4PXZ|rcsb pdb:4PY0|rcsb pdb:5DHG|rcsb pdb:8I7V|rcsb pdb:8I7W|rcsb pdb:8JPN|rcsb pdb:8JPP|rcsb pdb:8K9K|rcsb pdb:8RLN|rcsb pdb:8TH3|rcsb pdb:8TH4|rcsb pdb:8YRG|rcsb pdb:4RWA|rcsb pdb:4RWD|rcsb pdb:4U9D|rcsb pdb:4L6R|rcsb pdb:4N6H|rcsb pdb:4NC3|interpro:IPR009155(Cytochrome b562)|interpro:IPR010980(Cytochrome c and b562)|rcsb pdb:1APC|rcsb pdb:1LM3|rcsb pdb:1M6T|rcsb pdb:1QPU|rcsb pdb:1QQ3|rcsb pdb:256B|rcsb pdb:2BC5|rcsb pdb:2QLA|rcsb pdb:3C62|rcsb pdb:3C63|rcsb pdb:3DE8|rcsb pdb:3DE9|rcsb pdb:3FOO|rcsb pdb:3FOP|rcsb pdb:3HNI|rcsb pdb:3HNJ|rcsb pdb:3HNK|rcsb pdb:3HNL|rcsb pdb:3IQ5|rcsb pdb:3IQ6|rcsb pdb:3L1M|rcsb pdb:3M15|rcsb pdb:3M4B|rcsb pdb:6BQG|rcsb pdb:6BQH|rcsb pdb:5YO3|rcsb pdb:7EZC|rcsb pdb:7F4D|rcsb pdb:7F4F|rcsb pdb:7F4H|rcsb pdb:7F4I|rcsb pdb:7JNI|rcsb pdb:7LR5|rcsb pdb:7LRA|rcsb pdb:7LRB|rcsb pdb:7LRR|rcsb pdb:7LRV|rcsb pdb:7LSJ|rcsb pdb:7LSL|rcsb pdb:7LSN|rcsb pdb:7LV1|rcsb pdb:7LV4|rcsb pdb:7PX4|rcsb pdb:7PYR|rcsb pdb:7WVV|rcsb pdb:7WVW|rcsb pdb:7WVX|rcsb pdb:7WVY|rcsb pdb:6DY4|rcsb pdb:6DY6|rcsb pdb:6DY8|rcsb pdb:6DYB|rcsb pdb:6DYC|rcsb pdb:6DYD|rcsb pdb:6DYE|rcsb pdb:6DYF|rcsb pdb:6DYG|rcsb pdb:6DYH|rcsb pdb:6DYI|rcsb pdb:6DYJ|rcsb pdb:6DYK|rcsb pdb:6DYL|rcsb pdb:6M97|rcsb pdb:6M98|rcsb pdb:5UEN|rcsb pdb:4EIY|rcsb pdb:4IAR|rcsb pdb:4IB4|rcsb pdb:4JE9|rcsb pdb:4JEA|rcsb pdb:4JEB|rcsb pdb:4EA3|rcsb pdb:7F83|rcsb pdb:7F9Y|rcsb pdb:7F9Z|rcsb pdb:7S8M|rcsb pdb:7S8O|rcsb pdb:7S8P|rcsb pdb:7VOD|rcsb pdb:7VOE|rcsb pdb:4JKV|rcsb pdb:6S0Q|rcsb pdb:5WIU|rcsb pdb:5WIV|rcsb pdb:6LW5|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|rcsb pdb:6OT4|rcsb pdb:6OT7|rcsb pdb:6OT8|rcsb pdb:6OT9|rcsb pdb:6OVH|rcsb pdb:4O9R|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5L7D|rcsb pdb:5L7I|rcsb pdb:7ARO|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7KOO|rcsb pdb:7KOQ|rcsb pdb:7KOX|rcsb pdb:4NTJ|rcsb pdb:4OR2|rcsb pdb:6DO1|rcsb pdb:6CC4|rcsb pdb:6CMO|rcsb pdb:5BU7|rcsb pdb:4U9E|refseq:WP_001232240.1|rcsb pdb:6GT3|rcsb pdb:5YO4|rcsb pdb:5YO5|rcsb pdb:5YO6|rcsb pdb:4QIM|rcsb pdb:4QIN|rcsb pdb:6AK3|rcsb pdb:6G7O|rcsb pdb:6IIU|rcsb pdb:6IIV|rcsb pdb:4YAY|rcsb pdb:4Z34|rcsb pdb:4Z35|rcsb pdb:4Z36|rcsb pdb:4ZUD|rcsb pdb:5AWI|rcsb pdb:6ME6|rcsb pdb:6ME7|rcsb pdb:6ME8|rcsb pdb:6ME9|rcsb pdb:6MH8|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6WQA|rcsb pdb:7DFP|rcsb pdb:7JVR|rcsb pdb:8JT6|rcsb pdb:8FDO|rcsb pdb:8H2G|rcsb pdb:8JT8|rcsb pdb:8RQQ|rcsb pdb:8WRZ|rcsb pdb:8X2K|rcsb pdb:8XV2|rcsb pdb:8XV5|rcsb pdb:8XV9|rcsb pdb:6C1Q|rcsb pdb:6C1R|rcsb pdb:6D32|rcsb pdb:6D35|go:""GO:0005506""(iron ion binding)|go:""GO:0009055""(electron transfer activity)|go:""GO:0020037""(heme binding)|go:""GO:0022900""(electron transport chain)|go:""GO:0042597""(periplasmic space)|rcsb pdb:8FY8|rcsb pdb:8FYE|rcsb pdb:8FYL|rcsb pdb:8FYT|rcsb pdb:8FYX|rcsb pdb:8K9L|rcsb pdb:8TS1|rcsb pdb:8TS2|rcsb pdb:8TS3|rcsb pdb:8XVJ|rcsb pdb:8XVK|rcsb pdb:8XVL|rcsb pdb:8YZK|rcsb pdb:8ZFJ|rcsb pdb:8ZFK|rcsb pdb:8ZFL|rcsb pdb:8ZFM|rcsb pdb:8ZMF|rcsb pdb:8ZMG|rcsb pdb:8ZSJ|rcsb pdb:8ZSP|rcsb pdb:8ZSS|rcsb pdb:8ZSV|rcsb pdb:6UR8|rcsb pdb:6USF|rcsb pdb:5JTB|rcsb pdb:5UVI|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5L31|rcsb pdb:5L32|rcsb pdb:5TVN|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:5VRA|rcsb pdb:5XZI|rcsb pdb:5XZJ|rcsb pdb:6AQF|rcsb pdb:6B73|rcsb pdb:5UIG|rcsb pdb:5UNF|rcsb pdb:5UNG|rcsb pdb:5UNH|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|rcsb pdb:7EXD|rcsb pdb:7MYZ|rcsb pdb:7RM5|rcsb pdb:5DHH|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5N2S|rcsb pdb:5TUD|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5YM7|rcsb pdb:5XJM|rcsb pdb:6DHY|rcsb pdb:6DHZ|rcsb pdb:6DRX|rcsb pdb:6DRY|rcsb pdb:6DRZ|rcsb pdb:6DS0|rcsb pdb:7XRZ|rcsb pdb:7XY6|rcsb pdb:7XY7|rcsb pdb:7YIT|rcsb pdb:7ZL9|rcsb pdb:7ZLY|rcsb pdb:8F7C|rcsb pdb:8IBU|rcsb pdb:8IBV|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6CBV|rcsb pdb:6AI5|rcsb pdb:6JZH|rcsb pdb:6PS7|rcsb pdb:6RZ4|rcsb pdb:6RZ5|rcsb pdb:6IQL|rcsb pdb:6JOD|rcsb pdb:6RZ6|rcsb pdb:6RZ7|rcsb pdb:6RZ8|rcsb pdb:6RZ9|rcsb pdb:6KO5|rcsb pdb:6WW2|rcsb pdb:6WWZ|rcsb pdb:7BW0|rcsb pdb:7C61|rcsb pdb:7C6A|rcsb pdb:6WHA|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WYU|rcsb pdb:6WZ0|rcsb pdb:6WZ1|rcsb pdb:6WZ2|rcsb pdb:6WZ3|rcsb pdb:6WZ7|rcsb pdb:6WZA|rcsb pdb:6WZC|rcsb pdb:6X7E|rcsb pdb:6X8X|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:8HN8|rcsb pdb:8HOC|rcsb pdb:8IKJ|rcsb pdb:8J9O|rcsb pdb:8JH7|rcsb pdb:8JHC|rcsb pdb:8K8J|rcsb pdb:8UHB|rcsb pdb:8UT1|rcsb pdb:8UTB|rcsb pdb:8UZJ|rcsb pdb:8V80|rcsb pdb:8V82|rcsb pdb:8V86|rcsb pdb:8V88|rcsb pdb:8V89|rcsb pdb:8V8A|rcsb pdb:8V8C|rcsb pdb:8V8D|rcsb pdb:8W8Q|rcsb pdb:8X5X"	"rgd:2718|refseq:NP_112249.2|refseq:XP_006239579.1|refseq:XP_008762557.1|refseq:XP_017448634.1|refseq:XP_017448635.1|refseq:XP_017448636.1|refseq:XP_017448637.1|refseq:XP_017448638.1|dip:DIP-37029N|ensembl:ENSRNOG00000016638.6(gene)|ensembl:ENSRNOT00000041789.3(transcript)|go:""GO:0001750""(photoreceptor outer segment)|go:""GO:0001917""(photoreceptor inner segment)|go:""GO:0003924""(GTPase activity)|go:""GO:0005737""(cytoplasm)|go:""GO:0005834""(heterotrimeric G-protein complex)|go:""GO:0005886""(plasma membrane)|go:""GO:0007186""(G protein-coupled receptor signaling pathway)|go:""GO:0007200""(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:""GO:0007204""(positive regulation of cytosolic calcium ion concentration)|go:""GO:0008283""(cell population proliferation)|go:""GO:0010659""(cardiac muscle cell apoptotic process)|go:""GO:0030159""(signaling receptor complex adaptor activity)|go:""GO:0030425""(dendrite)|go:""GO:0030507""(spectrin binding)|go:""GO:0042622""(photoreceptor outer segment membrane)|go:""GO:0044297""(cell body)|go:""GO:0044877""(protein-containing complex binding)|go:""GO:0045202""(synapse)|go:""GO:0047391""(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:""GO:0050909""(sensory perception of taste)|go:""GO:0051020""(GTPase binding)|go:""GO:0060041""(retina development in camera-type eye)|go:""GO:0071456""(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P54311|rcsb pdb:3SN6|rcsb pdb:5TDH|rcsb pdb:5VAI|rcsb pdb:6CMO|rcsb pdb:6LPB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6WWZ|rcsb pdb:7BW0|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7DH5|rcsb pdb:7DTY|rcsb pdb:7DUQ|rcsb pdb:7DUR|rcsb pdb:7DW9|rcsb pdb:7EIB|rcsb pdb:7EQ1|rcsb pdb:7EVM|rcsb pdb:7F16|rcsb pdb:7F2O|rcsb pdb:7FIG|rcsb pdb:7FIH|rcsb pdb:7FII|rcsb pdb:7FIM|rcsb pdb:7FIN|rcsb pdb:7FIY|rcsb pdb:7LJC|rcsb pdb:7LJD|rcsb pdb:7MBX|rcsb pdb:7MBY|rcsb pdb:7PIU|rcsb pdb:7PIV|rcsb pdb:7T6S|rcsb pdb:7T6T|rcsb pdb:7T6U|rcsb pdb:7T6V|rcsb pdb:7TRY|rcsb pdb:7TS0|rcsb pdb:7V35|rcsb pdb:7V9L|rcsb pdb:7V9M|rcsb pdb:7VAB|rcsb pdb:7VBH|rcsb pdb:7VBI|rcsb pdb:7VGY|rcsb pdb:7VGZ|rcsb pdb:7VH0|rcsb pdb:7VQX|rcsb pdb:7VVJ|rcsb pdb:7VVK|rcsb pdb:7VVL|rcsb pdb:7VVM|rcsb pdb:7VVN|rcsb pdb:7VVO|rcsb pdb:7WBJ|rcsb pdb:7WIC|rcsb pdb:7WIG|rcsb pdb:7WQ3|rcsb pdb:7WQ4|rcsb pdb:7X8R|rcsb pdb:7X8S|rcsb pdb:7XJH|rcsb pdb:7XJI|rcsb pdb:7XW9|rcsb pdb:7XWO|rcsb pdb:7Y35|rcsb pdb:7Y36|rcsb pdb:7YU3|rcsb pdb:7YU5|rcsb pdb:7YU6|rcsb pdb:7YU7|rcsb pdb:7YU8|rcsb pdb:8EF5|rcsb pdb:8EF6|rcsb pdb:8EFB|rcsb pdb:8EFL|rcsb pdb:8EFO|rcsb pdb:8EFQ|rcsb pdb:8F7Q|rcsb pdb:8F7R|rcsb pdb:8F7S|rcsb pdb:8F7W|rcsb pdb:8F7X|rcsb pdb:8GW8|rcsb pdb:8HA0|rcsb pdb:8HAF|rcsb pdb:8HAO|rcsb pdb:8HK2|rcsb pdb:8HK3|rcsb pdb:8HK5|rcsb pdb:8ITL|rcsb pdb:8ITM|rcsb pdb:8IY5|rcsb pdb:8JBF|rcsb pdb:8JBG|rcsb pdb:8JBH|rcsb pdb:8JIP|rcsb pdb:8JIQ|rcsb pdb:8JIR|rcsb pdb:8JIS|rcsb pdb:8JIT|rcsb pdb:8JIU|rcsb pdb:8WA3|rcsb pdb:8WG7|rcsb pdb:8WG8|rcsb pdb:8WZ2|rcsb pdb:8X16|rcsb pdb:8X17|rcsb pdb:8XBE|rcsb pdb:8XBH|rcsb pdb:8XGR|rcsb pdb:8XOR|rcsb pdb:8XOS|rcsb pdb:8YKV|rcsb pdb:8YKW|rcsb pdb:8YKX|rcsb pdb:8ZBE|rcsb pdb:8ZCJ|rcsb pdb:8ZH8|rcsb pdb:9F33|rcsb pdb:9F34|rcsb pdb:9IJD|rcsb pdb:9IJE|rcsb pdb:9JR2|rcsb pdb:9JR3|reactome:R-RNO-1296041|reactome:R-RNO-202040|reactome:R-RNO-2485179|reactome:R-RNO-381676|reactome:R-RNO-392170|reactome:R-RNO-392451|reactome:R-RNO-400042|reactome:R-RNO-4086398|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-418597|reactome:R-RNO-420092|reactome:R-RNO-428930|reactome:R-RNO-432040|reactome:R-RNO-456926|reactome:R-RNO-6814122|reactome:R-RNO-8964616|reactome:R-RNO-9717207|reactome:R-RNO-9856530|reactome:R-RNO-997272|panther:PTHR19850(orthology-group)"	-	-	-	figure legend:Extended Data Fig 1a, b|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/17	2024/11/14	rogid:O9HPXjm/UQpqt+WPfwjDOEx8+m4562	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10116	intact-crc:243E383B8DB3BE4E|rigid:byUWCYFrBR1Dh68SItQ8WMUKU8E	false	-	-	1	1	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:2287""(identification by structure determination)"	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:2287""(identification by structure determination)"
uniprotkb:Q8X482	uniprotkb:O08816	intact:EBI-22229752	intact:EBI-6142604	"psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)"	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:""MI:0018""(two hybrid)"	Campellone et al. (2008)	pubmed:18974829|imex:IM-27627	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-25339660|imex:IM-27627-3	intact-miscore:0.76	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"go:""GO:0005576""(extracellular region)|go:""GO:0030430""(host cell cytoplasm)|interpro:IPR044889|interpro:IPR006891(EspF protein)|mint:Q8X482"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	-	-	-	"figure legend:fig. 7d|comment:""\""we examined this interaction in yeast two-hybrid assays. As demonstrated previously [28], the N-WASP GBD interacted with the C-terminus of EspFU that contains the repeat sequences, but not the EspFU N-terminus (Figure 7D). In addition, all of the C-terminal subfragments of EspFU, even those containing only a single repeat, interacted with the GBD in these assays. However, the degree of interaction did not positively correlate with increasing numbers of repeats. Rather, the number of repeats in EspFU inversely correlated with the degree of expression of the lacZ reporter.\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	"taxid:4932(yeasx)|taxid:4932(""Saccharomyces cerevisiae (Baker's yeast)"")"	-	2020/01/07	2024/11/14	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	intact-crc:EA111137632D7489|rigid:kpjsi7O6TBAKQFHiSDdtZHwSXD0	false	sufficient binding region:80-134|sufficient binding region:323-384|necessary binding region:80-384	binding-associated region:151-273	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q8X482	uniprotkb:O08816	intact:EBI-22229752	intact:EBI-6142604	"psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)"	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:""MI:0065""(isothermal titration calorimetry)"	Campellone et al. (2008)	pubmed:18974829|imex:IM-27627	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-25339679|imex:IM-27627-5	intact-miscore:0.76	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"go:""GO:0005576""(extracellular region)|go:""GO:0030430""(host cell cytoplasm)|interpro:IPR044889|interpro:IPR006891(EspF protein)|mint:Q8X482"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	-	-	-	figure legend:fig. 8a|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/07	2024/11/14	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	intact-crc:523FE7349F5DCDE4|rigid:kpjsi7O6TBAKQFHiSDdtZHwSXD0	false	binding-associated region:268-314|binding-associated region:221-314|binding-associated region:80-314	binding-associated region:151-273	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q8X482	uniprotkb:O08816	intact:EBI-22229752	intact:EBI-6142604	"psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)"	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:""MI:0071""(molecular sieving)"	Campellone et al. (2008)	pubmed:18974829|imex:IM-27627	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0914""(association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-25339792|imex:IM-27627-7	intact-miscore:0.76	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"go:""GO:0005576""(extracellular region)|go:""GO:0030430""(host cell cytoplasm)|interpro:IPR044889|interpro:IPR006891(EspF protein)|mint:Q8X482"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	-	-	-	"figure legend:fig. 8b|comment:""\""The single EspFU repeat bound N-WASP at essentially stoichiometric levels when mixed in equimolar (2 µM) quantities, as determined by an increase in the apparent size (i.e., earlier elution profile) of EspFU (Figure 8B left, red vs. blue peaks). The addition of 2 µM (i.e., a two-fold higher molar concentration) Arp2/3 caused ∼60% of the EspFU to shift to an even more rapidly eluting fraction indicative of an EspFU-N-WASP-Arp2/3 complex (Figure 8B, yellow profile). Very little of this complex was detected using 1 µM Arp2/3 (Figure 8B left, small shoulder in gray profile).\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/07	2024/11/14	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	intact-crc:6DD8E13E15884527|rigid:kpjsi7O6TBAKQFHiSDdtZHwSXD0	false	binding-associated region:268-314|binding-associated region:221-314	binding-associated region:193-501	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q8X482	uniprotkb:O08816	intact:EBI-22229752	intact:EBI-6142604	"psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)"	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:""MI:0018""(two hybrid)"	Campellone et al. (2004)	imex:IM-27522|pubmed:15296718	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-22229893|imex:IM-27522-17	intact-miscore:0.76	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"go:""GO:0005576""(extracellular region)|go:""GO:0030430""(host cell cytoplasm)|interpro:IPR044889|interpro:IPR006891(EspF protein)|mint:Q8X482"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	-	-	-	figure legend:fig. 6d|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2019/11/27	2024/11/14	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	intact-crc:3FC8F02C44F28D87|rigid:kpjsi7O6TBAKQFHiSDdtZHwSXD0	false	binding-associated region:80-384	necessary binding region:151-273	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q8X482	uniprotkb:O08816	intact:EBI-22229752	intact:EBI-6142604	"psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:""espF(U)""(gene name)|psi-mi:""espF(U)""(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)"	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)|uniprotkb:Neural Wiskott-Aldrich syndrome protein(gene name synonym)	"psi-mi:""MI:0018""(two hybrid)"	Cantarelli et al. (2007)	imex:IM-27552|pubmed:17451412	"taxid:83334(eco57)|taxid:83334(""Escherichia coli O157:H7"")"	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-22274805|imex:IM-27552-10	intact-miscore:0.76	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"go:""GO:0005576""(extracellular region)|go:""GO:0030430""(host cell cytoplasm)|interpro:IPR044889|interpro:IPR006891(EspF protein)|mint:Q8X482"	"mint:O08816|rgd:735144|dip:DIP-17016N|go:""GO:0000139""(Golgi membrane)|go:""GO:0003779""(actin binding)|go:""GO:0005634""(nucleus)|go:""GO:0005829""(cytosol)|go:""GO:0006900""(vesicle budding from membrane)|go:""GO:0008092""(cytoskeletal protein binding)|go:""GO:0009617""(response to bacterium)|go:""GO:0010324""(membrane invagination)|go:""GO:0016050""(vesicle organization)|go:""GO:0030027""(lamellipodium)|go:""GO:0030036""(actin cytoskeleton organization)|go:""GO:0030041""(actin filament polymerization)|go:""GO:0030050""(vesicle transport along actin filament)|go:""GO:0030478""(actin cap)|go:""GO:0031252""(cell leading edge)|go:""GO:0031410""(cytoplasmic vesicle)|go:""GO:0031503""(protein-containing complex localization)|go:""GO:0032880""(regulation of protein localization)|go:""GO:0042802""(identical protein binding)|go:""GO:0045944""(positive regulation of transcription by RNA polymerase II)|go:""GO:0050921""(positive regulation of chemotaxis)|go:""GO:0051301""(cell division)|go:""GO:0051491""(positive regulation of filopodium assembly)|go:""GO:0051653""(spindle localization)|go:""GO:0060491""(regulation of cell projection assembly)|go:""GO:0060997""(dendritic spine morphogenesis)|go:""GO:0097320""(plasma membrane tubulation)|go:""GO:0098794""(postsynapse)|go:""GO:0098974""(postsynaptic actin cytoskeleton organization)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099173""(postsynapse organization)|go:""GO:0099175""(regulation of postsynapse organization)|go:""GO:1903526""(negative regulation of membrane tubulation)|go:""GO:2000370""(positive regulation of clathrin-dependent endocytosis)|go:""GO:2000402""(negative regulation of lymphocyte migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|rcsb pdb:8S5T|panther:PTHR11202(orthology-group)"	-	-	-	"figure legend:fig. 4d|comment:""\""the Y2H assay confirmed the interaction between EspFu and N‐WASP (top, white bar), as well as between EspFu and the C‐terminus of cortactin (black bars). More importantly, in accordance with the previous results, our Y2H assay showed a strong interaction between EspFu and Cort Y/D form, as compared with the wild‐type or Cort S/D mutant.\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2019/12/02	2024/11/14	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	intact-crc:A75D2A3D7C1F603D|rigid:kpjsi7O6TBAKQFHiSDdtZHwSXD0	false	-	-	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:B0K022	uniprotkb:Q5ZWW6	intact:EBI-25746441|uniprotkb:F7FMT5	intact:EBI-25746433	psi-mi:b0k022_rat(display_long)|uniprotkb:Atp6v0b(gene name)|psi-mi:Atp6v0b(display_short)|uniprotkb:Atp6v0b_predicted(gene name synonym)|uniprotkb:rCG_50448(orf name)	psi-mi:q5zww6_legph(display_long)|uniprotkb:lpg0968(locus name)	"psi-mi:""MI:2339""(electron microscopy 3D single particle reconstruction)"	Abbas et al. (2020)	pubmed:32165585|imex:IM-28175	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-25745487|wwpdb:6VQ6|wwpdb:6VQ7|wwpdb:6VQ8|emdb:EMD-21317|emdb:EMD-21318|emdb:EMD-21319|imex:IM-28175-1	intact-miscore:0.32	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rgd:1308303|rcsb pdb:6VQC|rcsb pdb:6VQG|rcsb pdb:6VQH|rcsb pdb:6VQ8|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR035921|rcsb pdb:6VQ6|rcsb pdb:6VQ7|go:""GO:0005768""(endosome)|go:""GO:0016020""(membrane)|go:""GO:0030665""(clathrin-coated vesicle membrane)|go:""GO:0033176""(proton-transporting V-type ATPase complex)|go:""GO:0033179""(proton-transporting V-type ATPase, V0 domain)|go:""GO:0046961""(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:9B8O|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD"	rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:7U4T|rcsb pdb:7U8O|rcsb pdb:7U8P|rcsb pdb:7U8Q|rcsb pdb:7U8R|refseq:YP_095002.1|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|rcsb pdb:6WM2|rcsb pdb:6WM4|rcsb pdb:6WM3|rcsb pdb:6WLZ|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|refseq:WP_010946703.1|rcsb pdb:5UF5|rcsb pdb:5UFK	wwpdb:6VQ9(subset)|wwpdb:6VQA(subset)|wwpdb:6VQB(subset)|wwpdb:6VQC(subset)|wwpdb:6VQG(subset)|wwpdb:6VQH(subset)|wwpdb:6VQI(subset)|wwpdb:6VQJ(subset)|wwpdb:6VQK(subset)|emdb:EMD-21347(subset)|emdb:EMD-21345(subset)|emdb:EMD-21346(subset)|emdb:EMD-21348(subset)|emdb:EMD-21349(subset)|emdb:EMD-21350(subset)|emdb:EMD-21351(subset)|emdb:EMD-21352(subset)|emdb:EMD-21353(subset)	-	-	figure legend:Fig 1d, Fig S3|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/01	2024/11/14	rogid:++BxirRe+rnqf1UfZgQ6FX5Df/010116	rogid:maU05b/1dYWTmFHe1GDptBEQTio272624	intact-crc:4EDE7F56551EAAC7|rigid:s3baJLE0CDGP5KErSb0CkFWMIRc	false	-	binding-associated region:1-278|flag tag:c-c	1	3	"psi-mi:""MI:2287""(identification by structure determination)"	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:2287""(identification by structure determination)|psi-mi:""MI:0658""(multidimensional protein identification technology)"
uniprotkb:D4A133	uniprotkb:Q5ZWW6	intact:EBI-2257711|ensembl:ENSRNOP00000002727.6	intact:EBI-25746433	psi-mi:d4a133_rat(display_long)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:Atp6v1a(gene name)|psi-mi:Atp6v1a(display_short)	psi-mi:q5zww6_legph(display_long)|uniprotkb:lpg0968(locus name)	"psi-mi:""MI:0069""(mass spectrometry studies of complexes)"	Abbas et al. (2020)	pubmed:32165585|imex:IM-28175	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-25746587|imex:IM-28175-3	intact-miscore:0.40	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"ensembl:ENSRNOG00000001992.7(gene)|ensembl:ENSRNOT00000002727.6(transcript)|go:""GO:0000221""(vacuolar proton-transporting V-type ATPase, V1 domain)|go:""GO:0005524""(ATP binding)|go:""GO:0005654""(nucleoplasm)|go:""GO:0005737""(cytoplasm)|go:""GO:0005829""(cytosol)|go:""GO:0005886""(plasma membrane)|go:""GO:0005902""(microvillus)|go:""GO:0006879""(intracellular iron ion homeostasis)|go:""GO:0016020""(membrane)|go:""GO:0016324""(apical plasma membrane)|go:""GO:0016887""(ATP hydrolysis activity)|go:""GO:0030141""(secretory granule)|go:""GO:0030665""(clathrin-coated vesicle membrane)|go:""GO:0033176""(proton-transporting V-type ATPase complex)|go:""GO:0033180""(proton-transporting V-type ATPase, V1 domain)|go:""GO:0036295""(cellular response to increased oxygen levels)|go:""GO:0046933""(proton-transporting ATP synthase activity, rotational mechanism)|go:""GO:0046961""(proton-transporting ATPase activity, rotational mechanism)|go:""GO:0097401""(synaptic vesicle lumen acidification)|go:""GO:0098850""(extrinsic component of synaptic vesicle membrane)|go:""GO:1902600""(proton transmembrane transport)|go:""GO:1904949""(ATPase complex)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|interpro:IPR055190|mint:D4A133|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|reactome:R-RNO-1222556|reactome:R-RNO-77387|reactome:R-RNO-917977|reactome:R-RNO-9639288|reactome:R-RNO-983712|rgd:1596464|panther:PTHR43607(orthology-group)"	rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:7U4T|rcsb pdb:7U8O|rcsb pdb:7U8P|rcsb pdb:7U8Q|rcsb pdb:7U8R|refseq:YP_095002.1|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|rcsb pdb:6WM2|rcsb pdb:6WM4|rcsb pdb:6WM3|rcsb pdb:6WLZ|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|refseq:WP_010946703.1|rcsb pdb:5UF5|rcsb pdb:5UFK	wwpdb:6VQ9(subset)|wwpdb:6VQA(subset)|wwpdb:6VQB(subset)|wwpdb:6VQC(subset)|wwpdb:6VQG(subset)|wwpdb:6VQH(subset)|wwpdb:6VQI(subset)|wwpdb:6VQJ(subset)|wwpdb:6VQK(subset)|emdb:EMD-21347(subset)|emdb:EMD-21345(subset)|emdb:EMD-21346(subset)|emdb:EMD-21348(subset)|emdb:EMD-21349(subset)|emdb:EMD-21350(subset)|emdb:EMD-21351(subset)|emdb:EMD-21352(subset)|emdb:EMD-21353(subset)	-	-	figure legend:Fig 1c|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/01	2024/11/14	rogid:SFDTpXlgZ8ZBbA2gUjYXWfmNp6o10116	rogid:maU05b/1dYWTmFHe1GDptBEQTio272624	intact-crc:B13233B4A79CAE9F|rigid:3mgakXpVgrfooz135dXFKc0/wiI	false	-	binding-associated region:1-278|flag tag:c-c	3	3	"psi-mi:""MI:0427""(Identification by mass spectrometry)"	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:0427""(Identification by mass spectrometry)"
uniprotkb:D4A133	uniprotkb:Q5ZWW6	intact:EBI-2257711|ensembl:ENSRNOP00000002727.6	intact:EBI-25746433	psi-mi:d4a133_rat(display_long)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:Atp6v1a(gene name)|psi-mi:Atp6v1a(display_short)	psi-mi:q5zww6_legph(display_long)|uniprotkb:lpg0968(locus name)	"psi-mi:""MI:0069""(mass spectrometry studies of complexes)"	Abbas et al. (2020)	pubmed:32165585|imex:IM-28175	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-25746627|imex:IM-28175-5	intact-miscore:0.40	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"ensembl:ENSRNOG00000001992.7(gene)|ensembl:ENSRNOT00000002727.6(transcript)|go:""GO:0000221""(vacuolar proton-transporting V-type ATPase, V1 domain)|go:""GO:0005524""(ATP binding)|go:""GO:0005654""(nucleoplasm)|go:""GO:0005737""(cytoplasm)|go:""GO:0005829""(cytosol)|go:""GO:0005886""(plasma membrane)|go:""GO:0005902""(microvillus)|go:""GO:0006879""(intracellular iron ion homeostasis)|go:""GO:0016020""(membrane)|go:""GO:0016324""(apical plasma membrane)|go:""GO:0016887""(ATP hydrolysis activity)|go:""GO:0030141""(secretory granule)|go:""GO:0030665""(clathrin-coated vesicle membrane)|go:""GO:0033176""(proton-transporting V-type ATPase complex)|go:""GO:0033180""(proton-transporting V-type ATPase, V1 domain)|go:""GO:0036295""(cellular response to increased oxygen levels)|go:""GO:0046933""(proton-transporting ATP synthase activity, rotational mechanism)|go:""GO:0046961""(proton-transporting ATPase activity, rotational mechanism)|go:""GO:0097401""(synaptic vesicle lumen acidification)|go:""GO:0098850""(extrinsic component of synaptic vesicle membrane)|go:""GO:1902600""(proton transmembrane transport)|go:""GO:1904949""(ATPase complex)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|interpro:IPR055190|mint:D4A133|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|reactome:R-RNO-1222556|reactome:R-RNO-77387|reactome:R-RNO-917977|reactome:R-RNO-9639288|reactome:R-RNO-983712|rgd:1596464|panther:PTHR43607(orthology-group)"	rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:7U4T|rcsb pdb:7U8O|rcsb pdb:7U8P|rcsb pdb:7U8Q|rcsb pdb:7U8R|refseq:YP_095002.1|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|rcsb pdb:6WM2|rcsb pdb:6WM4|rcsb pdb:6WM3|rcsb pdb:6WLZ|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|refseq:WP_010946703.1|rcsb pdb:5UF5|rcsb pdb:5UFK	wwpdb:6VQ9(subset)|wwpdb:6VQA(subset)|wwpdb:6VQB(subset)|wwpdb:6VQC(subset)|wwpdb:6VQG(subset)|wwpdb:6VQH(subset)|wwpdb:6VQI(subset)|wwpdb:6VQJ(subset)|wwpdb:6VQK(subset)|emdb:EMD-21347(subset)|emdb:EMD-21345(subset)|emdb:EMD-21346(subset)|emdb:EMD-21348(subset)|emdb:EMD-21349(subset)|emdb:EMD-21350(subset)|emdb:EMD-21351(subset)|emdb:EMD-21352(subset)|emdb:EMD-21353(subset)	-	-	figure legend:Fig 1c|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/01	2024/11/14	rogid:SFDTpXlgZ8ZBbA2gUjYXWfmNp6o10116	rogid:maU05b/1dYWTmFHe1GDptBEQTio272624	intact-crc:BE1E56900858EF48|rigid:9ZghboB5nmS6LyVF/lIFCryCrQ8	false	-	binding-associated region:1-278|flag tag:c-c	1	1	"psi-mi:""MI:0427""(Identification by mass spectrometry)"	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:0427""(Identification by mass spectrometry)"
uniprotkb:D4A133	uniprotkb:Q5ZWW6	intact:EBI-2257711|ensembl:ENSRNOP00000002727.6	intact:EBI-25746433	psi-mi:d4a133_rat(display_long)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:Atp6v1a(gene name)|psi-mi:Atp6v1a(display_short)	psi-mi:q5zww6_legph(display_long)|uniprotkb:lpg0968(locus name)	"psi-mi:""MI:0069""(mass spectrometry studies of complexes)"	Abbas et al. (2020)	pubmed:32165585|imex:IM-28175	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-25746661|imex:IM-28175-7	intact-miscore:0.40	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"ensembl:ENSRNOG00000001992.7(gene)|ensembl:ENSRNOT00000002727.6(transcript)|go:""GO:0000221""(vacuolar proton-transporting V-type ATPase, V1 domain)|go:""GO:0005524""(ATP binding)|go:""GO:0005654""(nucleoplasm)|go:""GO:0005737""(cytoplasm)|go:""GO:0005829""(cytosol)|go:""GO:0005886""(plasma membrane)|go:""GO:0005902""(microvillus)|go:""GO:0006879""(intracellular iron ion homeostasis)|go:""GO:0016020""(membrane)|go:""GO:0016324""(apical plasma membrane)|go:""GO:0016887""(ATP hydrolysis activity)|go:""GO:0030141""(secretory granule)|go:""GO:0030665""(clathrin-coated vesicle membrane)|go:""GO:0033176""(proton-transporting V-type ATPase complex)|go:""GO:0033180""(proton-transporting V-type ATPase, V1 domain)|go:""GO:0036295""(cellular response to increased oxygen levels)|go:""GO:0046933""(proton-transporting ATP synthase activity, rotational mechanism)|go:""GO:0046961""(proton-transporting ATPase activity, rotational mechanism)|go:""GO:0097401""(synaptic vesicle lumen acidification)|go:""GO:0098850""(extrinsic component of synaptic vesicle membrane)|go:""GO:1902600""(proton transmembrane transport)|go:""GO:1904949""(ATPase complex)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|interpro:IPR055190|mint:D4A133|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|reactome:R-RNO-1222556|reactome:R-RNO-77387|reactome:R-RNO-917977|reactome:R-RNO-9639288|reactome:R-RNO-983712|rgd:1596464|panther:PTHR43607(orthology-group)"	rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:7U4T|rcsb pdb:7U8O|rcsb pdb:7U8P|rcsb pdb:7U8Q|rcsb pdb:7U8R|refseq:YP_095002.1|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|rcsb pdb:6WM2|rcsb pdb:6WM4|rcsb pdb:6WM3|rcsb pdb:6WLZ|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|refseq:WP_010946703.1|rcsb pdb:5UF5|rcsb pdb:5UFK	wwpdb:6VQ9(subset)|wwpdb:6VQA(subset)|wwpdb:6VQB(subset)|wwpdb:6VQC(subset)|wwpdb:6VQG(subset)|wwpdb:6VQH(subset)|wwpdb:6VQI(subset)|wwpdb:6VQJ(subset)|wwpdb:6VQK(subset)|emdb:EMD-21347(subset)|emdb:EMD-21345(subset)|emdb:EMD-21346(subset)|emdb:EMD-21348(subset)|emdb:EMD-21349(subset)|emdb:EMD-21350(subset)|emdb:EMD-21351(subset)|emdb:EMD-21352(subset)|emdb:EMD-21353(subset)	-	-	figure legend:Fig 1c|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/01	2024/11/14	rogid:SFDTpXlgZ8ZBbA2gUjYXWfmNp6o10116	rogid:maU05b/1dYWTmFHe1GDptBEQTio272624	intact-crc:9B63CA41099AA4FE|rigid:3mgakXpVgrfooz135dXFKc0/wiI	false	-	binding-associated region:1-278|flag tag:c-c	3	3	"psi-mi:""MI:0427""(Identification by mass spectrometry)"	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:0427""(Identification by mass spectrometry)"
uniprotkb:D4A133	uniprotkb:Q5ZWW6	intact:EBI-2257711|ensembl:ENSRNOP00000002727.6	intact:EBI-25746433	psi-mi:d4a133_rat(display_long)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:Atp6v1a(gene name)|psi-mi:Atp6v1a(display_short)	psi-mi:q5zww6_legph(display_long)|uniprotkb:lpg0968(locus name)	"psi-mi:""MI:0069""(mass spectrometry studies of complexes)"	Abbas et al. (2020)	pubmed:32165585|imex:IM-28175	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-25746693|imex:IM-28175-9	intact-miscore:0.40	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0497""(neutral component)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"ensembl:ENSRNOG00000001992.7(gene)|ensembl:ENSRNOT00000002727.6(transcript)|go:""GO:0000221""(vacuolar proton-transporting V-type ATPase, V1 domain)|go:""GO:0005524""(ATP binding)|go:""GO:0005654""(nucleoplasm)|go:""GO:0005737""(cytoplasm)|go:""GO:0005829""(cytosol)|go:""GO:0005886""(plasma membrane)|go:""GO:0005902""(microvillus)|go:""GO:0006879""(intracellular iron ion homeostasis)|go:""GO:0016020""(membrane)|go:""GO:0016324""(apical plasma membrane)|go:""GO:0016887""(ATP hydrolysis activity)|go:""GO:0030141""(secretory granule)|go:""GO:0030665""(clathrin-coated vesicle membrane)|go:""GO:0033176""(proton-transporting V-type ATPase complex)|go:""GO:0033180""(proton-transporting V-type ATPase, V1 domain)|go:""GO:0036295""(cellular response to increased oxygen levels)|go:""GO:0046933""(proton-transporting ATP synthase activity, rotational mechanism)|go:""GO:0046961""(proton-transporting ATPase activity, rotational mechanism)|go:""GO:0097401""(synaptic vesicle lumen acidification)|go:""GO:0098850""(extrinsic component of synaptic vesicle membrane)|go:""GO:1902600""(proton transmembrane transport)|go:""GO:1904949""(ATPase complex)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|interpro:IPR055190|mint:D4A133|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|reactome:R-RNO-1222556|reactome:R-RNO-77387|reactome:R-RNO-917977|reactome:R-RNO-9639288|reactome:R-RNO-983712|rgd:1596464|panther:PTHR43607(orthology-group)"	rcsb pdb:7UZF|rcsb pdb:7UZG|rcsb pdb:7UZH|rcsb pdb:7UZI|rcsb pdb:7UZJ|rcsb pdb:7UZK|rcsb pdb:7U4T|rcsb pdb:7U8O|rcsb pdb:7U8P|rcsb pdb:7U8Q|rcsb pdb:7U8R|refseq:YP_095002.1|rcsb pdb:9B8P|rcsb pdb:9BRB|rcsb pdb:9BRC|rcsb pdb:9BRD|rcsb pdb:6WM2|rcsb pdb:6WM4|rcsb pdb:6WM3|rcsb pdb:6WLZ|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|refseq:WP_010946703.1|rcsb pdb:5UF5|rcsb pdb:5UFK	wwpdb:6VQ9(subset)|wwpdb:6VQA(subset)|wwpdb:6VQB(subset)|wwpdb:6VQC(subset)|wwpdb:6VQG(subset)|wwpdb:6VQH(subset)|wwpdb:6VQI(subset)|wwpdb:6VQJ(subset)|wwpdb:6VQK(subset)|emdb:EMD-21351(subset)|emdb:EMD-21347(subset)|emdb:EMD-21345(subset)|emdb:EMD-21346(subset)|emdb:EMD-21348(subset)|emdb:EMD-21349(subset)|emdb:EMD-21350(subset)|emdb:EMD-21352(subset)|emdb:EMD-21353(subset)	-	-	figure legend:Fig 1c|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/01	2024/11/14	rogid:SFDTpXlgZ8ZBbA2gUjYXWfmNp6o10116	rogid:maU05b/1dYWTmFHe1GDptBEQTio272624	intact-crc:4AFFF59F3734B3BA|rigid:PkCFgPkIOQcwTzmQCe/pBBxzgMc	false	-	binding-associated region:1-278|flag tag:c-c	3	3	"psi-mi:""MI:0427""(Identification by mass spectrometry)"	"psi-mi:""MI:0396""(predetermined participant)|psi-mi:""MI:0427""(Identification by mass spectrometry)"
uniprotkb:P0DPI0	uniprotkb:Q9Z2I6	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9118756|imex:IM-22230-1	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	-	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"figure legend:f1a|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	intact-crc:28200A8B019DD9D1|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	his tag:?-?	glutathione s tranferase tag:?-?|binding-associated region:454-579	-	-	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"
uniprotkb:Q02563	uniprotkb:P0DPI0	intact:EBI-466194|uniprotkb:Q58DZ8|ensembl:ENSRNOP00000028760.2	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	psi-mi:sv2a_rat(display_long)|uniprotkb:Sv2a(gene name)|psi-mi:Sv2a(display_short)|uniprotkb:Sv2(gene name synonym)	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9118780|imex:IM-22230-2	intact-miscore:0.54	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"rgd:619715|refseq:NP_476558.2|refseq:XP_006233014.1|ensembl:ENSRNOG00000021182.6(gene)|ensembl:ENSRNOT00000028760.5(transcript)|go:""GO:0005783""(endoplasmic reticulum)|go:""GO:0005911""(cell-cell junction)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0006874""(intracellular calcium ion homeostasis)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0014052""(regulation of gamma-aminobutyric acid secretion)|go:""GO:0016082""(synaptic vesicle priming)|go:""GO:0019901""(protein kinase binding)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030425""(dendrite)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0043005""(neuron projection)|go:""GO:0043025""(neuronal cell body)|go:""GO:0043195""(terminal bouton)|go:""GO:0045202""(synapse)|go:""GO:0048786""(presynaptic active zone)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0098982""(GABA-ergic synapse)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q02563|panther:PTHR23511(orthology-group)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	-	-	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	"figure legend:sf1|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:a7TA6gTNT5eWAIVLxjT1dgUQzn410116	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	intact-crc:F31E7A53A43E3AFE|rigid:XRONUvQYt++Owq/3bScBAKn3MRM	false	binding-associated region:468-594|glutathione s tranferase tag:?-?	binding-associated region:449-1296|tandem tag:?-?	-	-	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"	"psi-mi:""MI:0818""(molecular weight estimation by coomasie staining)"
uniprotkb:P0DPI0	uniprotkb:Q9Z2I6	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9118895|imex:IM-22230-3	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	-	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	intact-crc:7E3B0C3CE7641568|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	mutation decreasing interaction:1131-1131|his tag:?-?	binding-associated region:454-579|glutathione s tranferase tag:?-?	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q9Z2I6	uniprotkb:P0DPI0	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9118929|imex:IM-22230-4	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	-	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	intact-crc:E2A61C7B42A1BD84|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	glutathione s tranferase tag:?-?|binding-associated region:454-579	his tag:?-?|mutation decreasing interaction:1163-1163	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q9Z2I6	uniprotkb:P0DPI0	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9118960|imex:IM-22230-5	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	-	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	intact-crc:7B5A4F54974E4FDE|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	glutathione s tranferase tag:?-?|binding-associated region:454-579	his tag:?-?|mutation decreasing interaction:1188-1188	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q9Z2I6	uniprotkb:P0DPI0	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9118977|imex:IM-22230-6	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	-	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	intact-crc:191BB2839EC192E9|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	binding-associated region:454-579|glutathione s tranferase tag:?-?	mutation decreasing interaction:905-905|his tag:?-?	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:P0DPI0	uniprotkb:Q9Z2I6	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9118993|imex:IM-22230-7	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	-	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	intact-crc:7B0D0EE124B23CDD|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	his tag:?-?|mutation decreasing interaction:1063-1063	binding-associated region:454-579|glutathione s tranferase tag:?-?	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q9Z2I6	uniprotkb:P0DPI0	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119010|imex:IM-22230-8	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	-	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	intact-crc:6199393E78919259|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	glutathione s tranferase tag:?-?|binding-associated region:454-579	his tag:?-?|mutation decreasing interaction:1064-1064	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:P0DPI0	uniprotkb:Q9Z2I6	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119028|imex:IM-22230-9	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	-	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	intact-crc:1DCF7BD1204BA885|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	his tag:?-?|mutation decreasing interaction:1108-1108	glutathione s tranferase tag:?-?|binding-associated region:454-579	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:P0DPI0	uniprotkb:Q9Z2I6	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119048|imex:IM-22230-10	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	-	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	intact-crc:E4245F410DA79503|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	his tag:?-?|mutation decreasing interaction:1156-1156	glutathione s tranferase tag:?-?|binding-associated region:454-579	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q9Z2I6	uniprotkb:P0DPI0	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119075|imex:IM-22230-11	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	-	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	"figure legend:f2|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	intact-crc:A680B8075BD57E0D|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	glutathione s tranferase tag:?-?|binding-associated region:454-579	his tag:?-?|mutation decreasing interaction:1287-1287	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:Q9Z2I6	uniprotkb:P0DPI0	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459.3	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	- (2014)	imex:IM-22230|pubmed:24583011	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119090|imex:IM-22230-12	intact-miscore:0.62	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:NP_113781.1|rgd:619718|refseq:XP_017446285.1|panther:PTHR23511(orthology-group)|ensembl:ENSRNOG00000018094.7(gene)|ensembl:ENSRNOT00000024459.7(transcript)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0098691""(dopaminergic synapse)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9Z2I6|rcsb pdb:5JMC"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	-	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	"figure legend:f|comment:""\""This direct protein-protein interaction is clearly demonstrated in a GST pull down assay  employing full-length recombinant H6tBoNTA and rat GST-rSV2C 454-579 (Fig. 1A). The  weaker binding of HCA to recombinant rat GST-rSV2A 468-594 is also shown (Fig. S1) whereas  binding to non-glycosylated rSV2B is hardly detectable. Well characterised neutralising  monoclonal antibodies directed against different epitopes within the HC-fragment of BoNT/A  [25-29] were screened for interference with the SV2C interaction\""""|curation depth:imex curation|full coverage:Only protein-protein interactions"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	intact-crc:45D3A3EDE470C9C5|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	binding-associated region:454-579|glutathione s tranferase tag:?-?	mutation decreasing interaction:1292-1292|his tag:?-?	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:P0DPI0	uniprotkb:Q02563	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	intact:EBI-466194|uniprotkb:Q58DZ8|ensembl:ENSRNOP00000028760.2	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	psi-mi:sv2a_rat(display_long)|uniprotkb:Sv2a(gene name)|psi-mi:Sv2a(display_short)|uniprotkb:Sv2(gene name synonym)	"psi-mi:""MI:0007""(anti tag coimmunoprecipitation)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119119|imex:IM-22230-13	intact-miscore:0.54	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	"rgd:619715|refseq:NP_476558.2|refseq:XP_006233014.1|ensembl:ENSRNOG00000021182.6(gene)|ensembl:ENSRNOT00000028760.5(transcript)|go:""GO:0005783""(endoplasmic reticulum)|go:""GO:0005911""(cell-cell junction)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0006874""(intracellular calcium ion homeostasis)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0014052""(regulation of gamma-aminobutyric acid secretion)|go:""GO:0016082""(synaptic vesicle priming)|go:""GO:0019901""(protein kinase binding)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030425""(dendrite)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0043005""(neuron projection)|go:""GO:0043025""(neuronal cell body)|go:""GO:0043195""(terminal bouton)|go:""GO:0045202""(synapse)|go:""GO:0048786""(presynaptic active zone)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0098982""(GABA-ergic synapse)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q02563|panther:PTHR23511(orthology-group)"	-	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	-	figure legend:f4|comment:HCA mutants R1156M and V1287E showed similar affinity to SV2A and SV2B as wild-type  HCA indicating subtle differences between the mode of interaction of SV2A/B and of SV2C with  BoNT/A|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	rogid:a7TA6gTNT5eWAIVLxjT1dgUQzn410116	intact-crc:5FA4DA876C65305B|rigid:7P2uuCdUTVkFX9T7CdRZckkemPI	false	tandem tag:?-?|binding-associated region:423-1251|mutation disrupting interaction:1292-1292	-	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:P0DPI0	uniprotkb:Q63564	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	intact:EBI-9254006	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	psi-mi:sv2b_rat(display_long)|uniprotkb:Sv2b(gene name)|psi-mi:Sv2b(display_short)|uniprotkb:Sv2bb(gene name synonym)	"psi-mi:""MI:0007""(anti tag coimmunoprecipitation)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119119|imex:IM-22230-13	intact-miscore:0.40	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|mint:P0DPI0|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|go:""GO:1905576""(ganglioside GT1b binding)|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2IMB|rcsb pdb:2IMC|rcsb pdb:2ISE|rcsb pdb:2ISG|rcsb pdb:2ISH|rcsb pdb:2VU9|rcsb pdb:2VUA|rcsb pdb:2W2D|rcsb pdb:3BOK|rcsb pdb:3BON|rcsb pdb:3BOO|rcsb pdb:3V0A|rcsb pdb:3V0B|rcsb pdb:3V0C|rcsb pdb:3ZUR|rcsb pdb:3ZUS|rcsb pdb:4HEV|rcsb pdb:4IQP|rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCD|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:7KYF|rcsb pdb:7KYH|rcsb pdb:7LZP|rcsb pdb:7M1H|reactome:R-HSA-5250968"	"interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR005828(General substrate transporter)|interpro:IPR022308|rgd:619716|refseq:NP_476555.1|interpro:IPR036259|go:""GO:0001504""(neurotransmitter uptake)|go:""GO:0001669""(acrosomal vesicle)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099509""(regulation of presynaptic cytosolic calcium ion concentration)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|mint:Q63564|panther:PTHR23511(orthology-group)"	-	"comment:mint|function:""\""Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure\"""""	-	figure legend:f4|comment:HCA mutants R1156M and V1287E showed similar affinity to SV2A and SV2B as wild-type  HCA indicating subtle differences between the mode of interaction of SV2A/B and of SV2C with  BoNT/A|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	rogid:PnkAiRP4l+Bkf3cK1gDGTPCsT/810116	intact-crc:5FA4DA876C65305B|rigid:7P2uuCdUTVkFX9T7CdRZckkemPI	false	tandem tag:?-?|binding-associated region:423-1251|mutation disrupting interaction:1292-1292	-	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:Q00496	uniprotkb:Q02563	intact:EBI-9119157|uniprotkb:Q45862	intact:EBI-466194|uniprotkb:Q58DZ8|ensembl:ENSRNOP00000028760.2	psi-mi:bxe_clobo(display_long)|uniprotkb:botE(gene name)|psi-mi:botE(display_short)|uniprotkb:Bontoxilysin-E(gene name synonym)	psi-mi:sv2a_rat(display_long)|uniprotkb:Sv2a(gene name)|psi-mi:Sv2a(display_short)|uniprotkb:Sv2(gene name synonym)	"psi-mi:""MI:0007""(anti tag coimmunoprecipitation)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119190|imex:IM-22230-14	intact-miscore:0.40	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"rcsb pdb:7UIE|reactome:R-HSA-5250992|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1T3A|rcsb pdb:1T3C|rcsb pdb:1ZKW|rcsb pdb:1ZKX|rcsb pdb:1ZL5|rcsb pdb:1ZL6|rcsb pdb:1ZN3|rcsb pdb:3FFZ|rcsb pdb:7K7Y|rcsb pdb:7K84|rcsb pdb:7QFP|rcsb pdb:7UIA|rcsb pdb:7UIB|refseq:WP_003372387.1|dip:DIP-46083N|mint:Q00496"	"rgd:619715|refseq:NP_476558.2|refseq:XP_006233014.1|ensembl:ENSRNOG00000021182.6(gene)|ensembl:ENSRNOT00000028760.5(transcript)|go:""GO:0005783""(endoplasmic reticulum)|go:""GO:0005911""(cell-cell junction)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0006874""(intracellular calcium ion homeostasis)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0014052""(regulation of gamma-aminobutyric acid secretion)|go:""GO:0016082""(synaptic vesicle priming)|go:""GO:0019901""(protein kinase binding)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030425""(dendrite)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0043005""(neuron projection)|go:""GO:0043025""(neuronal cell body)|go:""GO:0043195""(terminal bouton)|go:""GO:0045202""(synapse)|go:""GO:0048786""(presynaptic active zone)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0098982""(GABA-ergic synapse)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q02563|panther:PTHR23511(orthology-group)"	-	-	-	figure legend:f4|comment:HCA mutants R1156M and V1287E showed similar affinity to SV2A and SV2B as wild-type  HCA indicating subtle differences between the mode of interaction of SV2A/B and of SV2C with  BoNT/A|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:zOobvRGIyO5Ji/AoLT/+CNWua001491	rogid:a7TA6gTNT5eWAIVLxjT1dgUQzn410116	intact-crc:E22867A8F6F8C5F7|rigid:imXaCUupO6pQlUHq0CF1KOTXuA8	false	binding-associated region:423-1251|tandem tag:?-?	-	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:Q00496	uniprotkb:Q63564	intact:EBI-9119157|uniprotkb:Q45862	intact:EBI-9254006	psi-mi:bxe_clobo(display_long)|uniprotkb:botE(gene name)|psi-mi:botE(display_short)|uniprotkb:Bontoxilysin-E(gene name synonym)	psi-mi:sv2b_rat(display_long)|uniprotkb:Sv2b(gene name)|psi-mi:Sv2b(display_short)|uniprotkb:Sv2bb(gene name synonym)	"psi-mi:""MI:0007""(anti tag coimmunoprecipitation)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119190|imex:IM-22230-14	intact-miscore:0.40	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"rcsb pdb:7UIE|reactome:R-HSA-5250992|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1T3A|rcsb pdb:1T3C|rcsb pdb:1ZKW|rcsb pdb:1ZKX|rcsb pdb:1ZL5|rcsb pdb:1ZL6|rcsb pdb:1ZN3|rcsb pdb:3FFZ|rcsb pdb:7K7Y|rcsb pdb:7K84|rcsb pdb:7QFP|rcsb pdb:7UIA|rcsb pdb:7UIB|refseq:WP_003372387.1|dip:DIP-46083N|mint:Q00496"	"interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR005828(General substrate transporter)|interpro:IPR022308|rgd:619716|refseq:NP_476555.1|interpro:IPR036259|go:""GO:0001504""(neurotransmitter uptake)|go:""GO:0001669""(acrosomal vesicle)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099509""(regulation of presynaptic cytosolic calcium ion concentration)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|mint:Q63564|panther:PTHR23511(orthology-group)"	-	-	-	figure legend:f4|comment:HCA mutants R1156M and V1287E showed similar affinity to SV2A and SV2B as wild-type  HCA indicating subtle differences between the mode of interaction of SV2A/B and of SV2C with  BoNT/A|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:zOobvRGIyO5Ji/AoLT/+CNWua001491	rogid:PnkAiRP4l+Bkf3cK1gDGTPCsT/810116	intact-crc:E22867A8F6F8C5F7|rigid:imXaCUupO6pQlUHq0CF1KOTXuA8	false	binding-associated region:423-1251|tandem tag:?-?	-	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:P30996	uniprotkb:Q63564	intact:EBI-9119207	intact:EBI-9254006	psi-mi:bxf_clobo(display_long)|uniprotkb:botF(gene name)|psi-mi:botF(display_short)|uniprotkb:Bontoxilysin-F(gene name synonym)	psi-mi:sv2b_rat(display_long)|uniprotkb:Sv2b(gene name)|psi-mi:Sv2b(display_short)|uniprotkb:Sv2bb(gene name synonym)	"psi-mi:""MI:0007""(anti tag coimmunoprecipitation)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119236|imex:IM-22230-15	intact-miscore:0.40	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR012500(Clostridium neurotoxin, translocation)|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|rcsb pdb:2A8A|rcsb pdb:2A97|reactome:R-HSA-5250981|interpro:IPR036248|mint:P30996"	"interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR005828(General substrate transporter)|interpro:IPR022308|rgd:619716|refseq:NP_476555.1|interpro:IPR036259|go:""GO:0001504""(neurotransmitter uptake)|go:""GO:0001669""(acrosomal vesicle)|go:""GO:0007268""(chemical synaptic transmission)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099509""(regulation of presynaptic cytosolic calcium ion concentration)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|mint:Q63564|panther:PTHR23511(orthology-group)"	-	-	-	figure legend:f4|comment:HCA mutants R1156M and V1287E showed similar affinity to SV2A and SV2B as wild-type  HCA indicating subtle differences between the mode of interaction of SV2A/B and of SV2C with  BoNT/A|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:VkdPeGwB+fU9RbXbftw8PkIJTLo1491	rogid:PnkAiRP4l+Bkf3cK1gDGTPCsT/810116	intact-crc:32DEFF1DDE7E8998|rigid:RT6tuTQ9wR8CiGBXyLmJgwZu26Q	false	binding-associated region:437-1274|tandem tag:?-?	-	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:P30996	uniprotkb:Q02563	intact:EBI-9119207	intact:EBI-466194|uniprotkb:Q58DZ8|ensembl:ENSRNOP00000028760.2	psi-mi:bxf_clobo(display_long)|uniprotkb:botF(gene name)|psi-mi:botF(display_short)|uniprotkb:Bontoxilysin-F(gene name synonym)	psi-mi:sv2a_rat(display_long)|uniprotkb:Sv2a(gene name)|psi-mi:Sv2a(display_short)|uniprotkb:Sv2(gene name synonym)	"psi-mi:""MI:0007""(anti tag coimmunoprecipitation)"	- (2014)	imex:IM-22230|pubmed:24583011	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0471""(MINT)"	intact:EBI-9119236|imex:IM-22230-15	intact-miscore:0.40	"psi-mi:""MI:1060""(spoke expansion)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR012500(Clostridium neurotoxin, translocation)|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|rcsb pdb:2A8A|rcsb pdb:2A97|reactome:R-HSA-5250981|interpro:IPR036248|mint:P30996"	"rgd:619715|refseq:NP_476558.2|refseq:XP_006233014.1|ensembl:ENSRNOG00000021182.6(gene)|ensembl:ENSRNOT00000028760.5(transcript)|go:""GO:0005783""(endoplasmic reticulum)|go:""GO:0005911""(cell-cell junction)|go:""GO:0006836""(neurotransmitter transport)|go:""GO:0006874""(intracellular calcium ion homeostasis)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0014052""(regulation of gamma-aminobutyric acid secretion)|go:""GO:0016082""(synaptic vesicle priming)|go:""GO:0019901""(protein kinase binding)|go:""GO:0022857""(transmembrane transporter activity)|go:""GO:0030425""(dendrite)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0043005""(neuron projection)|go:""GO:0043025""(neuronal cell body)|go:""GO:0043195""(terminal bouton)|go:""GO:0045202""(synapse)|go:""GO:0048786""(presynaptic active zone)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0098982""(GABA-ergic synapse)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q02563|panther:PTHR23511(orthology-group)"	-	-	-	figure legend:f4|comment:HCA mutants R1156M and V1287E showed similar affinity to SV2A and SV2B as wild-type  HCA indicating subtle differences between the mode of interaction of SV2A/B and of SV2C with  BoNT/A|curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2025/03/31	rogid:VkdPeGwB+fU9RbXbftw8PkIJTLo1491	rogid:a7TA6gTNT5eWAIVLxjT1dgUQzn410116	intact-crc:32DEFF1DDE7E8998|rigid:RT6tuTQ9wR8CiGBXyLmJgwZu26Q	false	binding-associated region:437-1274|tandem tag:?-?	-	-	-	"psi-mi:""MI:0113""(western blot)"	"psi-mi:""MI:0113""(western blot)"
uniprotkb:P10844	uniprotkb:P21707	intact:EBI-7661991|uniprotkb:P10843|intact:MINT-1795550	intact:EBI-458098|uniprotkb:Q3S2E6|uniprotkb:Q707P5|ensembl:ENSRNOP00000049624.2	psi-mi:bxb_clobo(display_long)|uniprotkb:botB(gene name)|psi-mi:botB(display_short)|uniprotkb:Bontoxilysin-B(gene name synonym)	psi-mi:syt1_rat(display_long)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Chai et al. (2006)	pubmed:17167418|doi:10.1038/nature05411|imex:IM-21618	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0915""(physical association)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-15615680|imex:IM-21618-2|dip:DIP-192035E	intact-miscore:0.40	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:WP_012291519.1|dip:DIP-42782N|mint:P10844|rcsb pdb:1F31|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1EPW|rcsb pdb:1F82|rcsb pdb:1G9A|rcsb pdb:1G9B|rcsb pdb:1G9C|rcsb pdb:1G9D|rcsb pdb:1I1E|rcsb pdb:1S0B|rcsb pdb:1S0C|rcsb pdb:1S0D|rcsb pdb:1S0E|rcsb pdb:1S0F|rcsb pdb:1S0G|rcsb pdb:1Z0H|rcsb pdb:2ETF|rcsb pdb:2NM1|rcsb pdb:2NP0|rcsb pdb:2XHL|rcsb pdb:3ZUQ|rcsb pdb:4KBB|rcsb pdb:5VID|rcsb pdb:5VMR|rcsb pdb:6G5F|rcsb pdb:6G5G|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6UC6|rcsb pdb:6UFT|rcsb pdb:6UHT|rcsb pdb:6UL4|rcsb pdb:7NA9|rcsb pdb:7QFQ|rcsb pdb:7T5F|reactome:R-HSA-5250958"	"rgd:3803|refseq:NP_001028852.2|ensembl:ENSRNOG00000006426.7(gene)|ensembl:ENSRNOT00000048880.3(transcript)|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005513""(detection of calcium ion)|go:""GO:0005516""(calmodulin binding)|go:""GO:0005543""(phospholipid binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005546""(phosphatidylinositol-4,5-bisphosphate binding)|go:""GO:0005737""(cytoplasm)|go:""GO:0005794""(Golgi apparatus)|go:""GO:0005886""(plasma membrane)|go:""GO:0006906""(vesicle fusion)|go:""GO:0007269""(neurotransmitter secretion)|go:""GO:0008021""(synaptic vesicle)|go:""GO:0008289""(lipid binding)|go:""GO:0014059""(regulation of dopamine secretion)|go:""GO:0014069""(postsynaptic density)|go:""GO:0016050""(vesicle organization)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017075""(syntaxin-1 binding)|go:""GO:0017156""(calcium-ion regulated exocytosis)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030141""(secretory granule)|go:""GO:0030154""(cell differentiation)|go:""GO:0030276""(clathrin binding)|go:""GO:0030348""(syntaxin-3 binding)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031338""(regulation of vesicle fusion)|go:""GO:0031340""(positive regulation of vesicle fusion)|go:""GO:0033603""(positive regulation of dopamine secretion)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0042734""(presynaptic membrane)|go:""GO:0042802""(identical protein binding)|go:""GO:0043005""(neuron projection)|go:""GO:0043195""(terminal bouton)|go:""GO:0044306""(neuron projection terminus)|go:""GO:0045211""(postsynaptic membrane)|go:""GO:0045956""(positive regulation of calcium ion-dependent exocytosis)|go:""GO:0046982""(protein heterodimerization activity)|go:""GO:0048278""(vesicle docking)|go:""GO:0048306""(calcium-dependent protein binding)|go:""GO:0048786""(presynaptic active zone)|go:""GO:0048791""(calcium ion-regulated exocytosis of neurotransmitter)|go:""GO:0050750""(low-density lipoprotein particle receptor binding)|go:""GO:0050806""(positive regulation of synaptic transmission)|go:""GO:0051291""(protein heterooligomerization)|go:""GO:0051592""(response to calcium ion)|go:""GO:0051966""(regulation of synaptic transmission, glutamatergic)|go:""GO:0060076""(excitatory synapse)|go:""GO:0061669""(spontaneous neurotransmitter secretion)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0071277""(cellular response to calcium ion)|go:""GO:0071911""(synchronous neurotransmitter secretion)|go:""GO:0098686""(hippocampal mossy fiber to CA3 synapse)|go:""GO:0098746""(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:""GO:0098978""(glutamatergic synapse)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:0099523""(presynaptic cytosol)|go:""GO:0099524""(postsynaptic cytosol)|go:""GO:0140693""(molecular condensate scaffold activity)|go:""GO:0140694""(membraneless organelle assembly)|go:""GO:1903235""(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:""GO:1903305""(regulation of regulated secretory pathway)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|mint:P21707|rcsb pdb:1BYN|rcsb pdb:1K5W|rcsb pdb:1RSY|rcsb pdb:1TJM|rcsb pdb:1TJX|rcsb pdb:1UOV|rcsb pdb:1UOW|rcsb pdb:2YOA|rcsb pdb:4WEE|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5CCJ|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6CXW|rcsb pdb:6MTI|rcsb pdb:8C5H|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-888590|refseq:XP_017450168.1|dip:DIP-29064N|panther:PTHR10024(orthology-group)"	"psi-mi:""MI:0465""(dip)"	"comment:mint|function:""\""Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2\"""""	-	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2025/01/27	rogid:TyP1/JJzdgNBsIqolX4P5Vc+9Ag1491	rogid:fr7zfj22zAOY/bJ7psjrgnsb0g810116	intact-crc:07E8EB5D2526128B|rigid:+4wTeRunz8/i0hU47b4ADFTL4HY	false	-	sufficient binding region:1-265|glutathione s tranferase tag:n-n	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:P10844	uniprotkb:P29101	intact:EBI-7661991|uniprotkb:P10843|intact:MINT-1795550	intact:EBI-458017	psi-mi:bxb_clobo(display_long)|uniprotkb:botB(gene name)|psi-mi:botB(display_short)|uniprotkb:Bontoxilysin-B(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	"psi-mi:""MI:0065""(isothermal titration calorimetry)"	Jin et al. (2006)	pubmed:17167421|doi:10.1038/nature05387|imex:IM-21619	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-15615934|imex:IM-21619-1|dip:DIP-72743E	intact-miscore:0.77	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:WP_012291519.1|dip:DIP-42782N|mint:P10844|rcsb pdb:1F31|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1EPW|rcsb pdb:1F82|rcsb pdb:1G9A|rcsb pdb:1G9B|rcsb pdb:1G9C|rcsb pdb:1G9D|rcsb pdb:1I1E|rcsb pdb:1S0B|rcsb pdb:1S0C|rcsb pdb:1S0D|rcsb pdb:1S0E|rcsb pdb:1S0F|rcsb pdb:1S0G|rcsb pdb:1Z0H|rcsb pdb:2ETF|rcsb pdb:2NM1|rcsb pdb:2NP0|rcsb pdb:2XHL|rcsb pdb:3ZUQ|rcsb pdb:4KBB|rcsb pdb:5VID|rcsb pdb:5VMR|rcsb pdb:6G5F|rcsb pdb:6G5G|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6UC6|rcsb pdb:6UFT|rcsb pdb:6UHT|rcsb pdb:6UL4|rcsb pdb:7NA9|rcsb pdb:7QFQ|rcsb pdb:7T5F|reactome:R-HSA-5250958"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)"	"psi-mi:""MI:0465""(dip)"	"comment:mint|function:""\""Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2\"""""	-	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2024/11/14	rogid:TyP1/JJzdgNBsIqolX4P5Vc+9Ag1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:715C91BBE5DAAABE|rigid:5VTvp7jz8LSWDObE8OcmI6JyJJQ	false	sufficient binding region:858-1291	sufficient binding region:1-61	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:P10844	uniprotkb:P29101	intact:EBI-7661991|uniprotkb:P10843|intact:MINT-1795550	intact:EBI-458017	psi-mi:bxb_clobo(display_long)|uniprotkb:botB(gene name)|psi-mi:botB(display_short)|uniprotkb:Bontoxilysin-B(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Jin et al. (2006)	pubmed:17167421|doi:10.1038/nature05387|imex:IM-21619	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-15615955|imex:IM-21619-2|dip:DIP-72743E	intact-miscore:0.77	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:WP_012291519.1|dip:DIP-42782N|mint:P10844|rcsb pdb:1F31|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1EPW|rcsb pdb:1F82|rcsb pdb:1G9A|rcsb pdb:1G9B|rcsb pdb:1G9C|rcsb pdb:1G9D|rcsb pdb:1I1E|rcsb pdb:1S0B|rcsb pdb:1S0C|rcsb pdb:1S0D|rcsb pdb:1S0E|rcsb pdb:1S0F|rcsb pdb:1S0G|rcsb pdb:1Z0H|rcsb pdb:2ETF|rcsb pdb:2NM1|rcsb pdb:2NP0|rcsb pdb:2XHL|rcsb pdb:3ZUQ|rcsb pdb:4KBB|rcsb pdb:5VID|rcsb pdb:5VMR|rcsb pdb:6G5F|rcsb pdb:6G5G|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6UC6|rcsb pdb:6UFT|rcsb pdb:6UHT|rcsb pdb:6UL4|rcsb pdb:7NA9|rcsb pdb:7QFQ|rcsb pdb:7T5F|reactome:R-HSA-5250958"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)"	"psi-mi:""MI:0465""(dip)"	"comment:mint|function:""\""Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2\"""""	-	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2024/11/14	rogid:TyP1/JJzdgNBsIqolX4P5Vc+9Ag1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:16F08FF14447947D|rigid:5VTvp7jz8LSWDObE8OcmI6JyJJQ	false	sufficient binding region:858-1291|mutation decreasing interaction strength:1118-1118|mutation decreasing interaction strength:1192-1192|mutation disrupting interaction strength:1194-1194|mutation disrupting interaction strength:1196-1196|mutation disrupting interaction strength:1204-1204	glutathione s tranferase tag:n-n|sufficient binding region:1-61	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
uniprotkb:P10844	uniprotkb:P29101	intact:EBI-7661991|uniprotkb:P10843|intact:MINT-1795550	intact:EBI-458017	psi-mi:bxb_clobo(display_long)|uniprotkb:botB(gene name)|psi-mi:botB(display_short)|uniprotkb:Bontoxilysin-B(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	"psi-mi:""MI:0096""(pull down)"	Jin et al. (2006)	pubmed:17167421|doi:10.1038/nature05387|imex:IM-21619	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	"taxid:10116(rat)|taxid:10116(""Rattus norvegicus (Rat)"")"	"psi-mi:""MI:0407""(direct interaction)"	"psi-mi:""MI:0465""(DIP)"	intact:EBI-15615992|imex:IM-21619-3|dip:DIP-72743E	intact-miscore:0.77	-	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0499""(unspecified role)"	"psi-mi:""MI:0498""(prey)"	"psi-mi:""MI:0496""(bait)"	"psi-mi:""MI:0326""(protein)"	"psi-mi:""MI:0326""(protein)"	"refseq:WP_012291519.1|dip:DIP-42782N|mint:P10844|rcsb pdb:1F31|go:""GO:0004222""(metalloendopeptidase activity)|go:""GO:0005576""(extracellular region)|go:""GO:0006508""(proteolysis)|go:""GO:0008270""(zinc ion binding)|go:""GO:0008289""(lipid binding)|go:""GO:0008320""(protein transmembrane transporter activity)|go:""GO:0016020""(membrane)|go:""GO:0020002""(host cell plasma membrane)|go:""GO:0044161""(host cell cytoplasmic vesicle)|go:""GO:0044164""(host cell cytosol)|go:""GO:0044231""(host cell presynaptic membrane)|go:""GO:0090729""(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1EPW|rcsb pdb:1F82|rcsb pdb:1G9A|rcsb pdb:1G9B|rcsb pdb:1G9C|rcsb pdb:1G9D|rcsb pdb:1I1E|rcsb pdb:1S0B|rcsb pdb:1S0C|rcsb pdb:1S0D|rcsb pdb:1S0E|rcsb pdb:1S0F|rcsb pdb:1S0G|rcsb pdb:1Z0H|rcsb pdb:2ETF|rcsb pdb:2NM1|rcsb pdb:2NP0|rcsb pdb:2XHL|rcsb pdb:3ZUQ|rcsb pdb:4KBB|rcsb pdb:5VID|rcsb pdb:5VMR|rcsb pdb:6G5F|rcsb pdb:6G5G|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6UC6|rcsb pdb:6UFT|rcsb pdb:6UHT|rcsb pdb:6UL4|rcsb pdb:7NA9|rcsb pdb:7QFQ|rcsb pdb:7T5F|reactome:R-HSA-5250958"	"mint:P29101|rgd:3804|refseq:NP_036797.1|go:""GO:0000149""(SNARE binding)|go:""GO:0001786""(phosphatidylserine binding)|go:""GO:0005509""(calcium ion binding)|go:""GO:0005544""(calcium-dependent phospholipid binding)|go:""GO:0005886""(plasma membrane)|go:""GO:0016079""(synaptic vesicle exocytosis)|go:""GO:0016192""(vesicle-mediated transport)|go:""GO:0017158""(regulation of calcium ion-dependent exocytosis)|go:""GO:0019905""(syntaxin binding)|go:""GO:0030154""(cell differentiation)|go:""GO:0030424""(axon)|go:""GO:0030672""(synaptic vesicle membrane)|go:""GO:0031045""(dense core granule)|go:""GO:0031594""(neuromuscular junction)|go:""GO:0042584""(chromaffin granule membrane)|go:""GO:0043195""(terminal bouton)|go:""GO:0043533""(inositol 1,3,4,5 tetrakisphosphate binding)|go:""GO:0061891""(calcium ion sensor activity)|go:""GO:0070382""(exocytic vesicle)|go:""GO:0099502""(calcium-dependent activation of synaptic vesicle fusion)|go:""GO:1903861""(positive regulation of dendrite extension)|go:""GO:2000300""(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-32642N|panther:PTHR10024(orthology-group)"	"psi-mi:""MI:0465""(dip)"	"comment:mint|function:""\""Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2\"""""	-	curation depth:imex curation|full coverage:Only protein-protein interactions	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2024/11/14	rogid:TyP1/JJzdgNBsIqolX4P5Vc+9Ag1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:839F90FCB60E3A8D|rigid:5VTvp7jz8LSWDObE8OcmI6JyJJQ	false	sufficient binding region:858-1291	sufficient binding region:1-61|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:47-47|mutation disrupting interaction strength:54-54|mutation disrupting interaction strength:55-55|mutation disrupting interaction strength:57-57|mutation decreasing interaction strength:50-50	-	-	"psi-mi:""MI:0396""(predetermined participant)"	"psi-mi:""MI:0396""(predetermined participant)"
