Browse-BactMentha

Display specific BactMentha datasets

BactMentha dataset filtered on host taxa:

Click on a taxon button to display the BactMentha database pathogen-host protein-protein interactions for the corresponding host taxon.
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All Data

Human

Mouse

Rat

BactMentha dataset filtered on pathogen categories:

The World Health Organization (WHO) Priority Pathogens are infectious microorganisms considered a significant threat to global public health, often due to their potential for causing severe outbreaks or limited treatment options. According to the European Union classification system of biological agents, hazard groups (from 1 to 4) categorize, based on their risk, those which may affect the human health (https://www.hse.gov.uk/pubns/misc208.pdf). Click on the following buttons to filter the BactMentha Dataset and display only the interactions involving pathogens in either WHO priority list or in an Hazard group. (Filter on Hazard groups 1 and 4 have not been added as no such pathogens are found in BactMentha).

Who priority
or
Hazard groups

Who priority

Hazard group 2

Hazard group 3

BactMentha dataset filtered on annotated protein interactions:

Available data on experimentally detected binding regions have been gathered from IMEx databases, thus providing the details on the sequence regions of either bacteria or host proteins (or both) involved in the interactions. The Ontology Search (OS) definition describing these binding regions can be found here. Moreover, the mimicINT workflow has been used to predict the interaction interfaces between Human proteins and bacterial proteins based on known domain-domain or domain-motif interaction templates. We also provide AlphaFold-predicted complex structure for a subset of interactions between annotated bacterial and human proteins. Click on the following buttons to display only the Human-Bacteria protein-protein interactions for which there are known experimental binding regions (BR) on at least one interacting protein or mimicINT predicted interaction interfaces (MI) of interaction (predicted regions are for both proteins) or AlphaFold-predicted complex structure (AF).

Binding regions

mimicINT interfaces

AlphaFold complexes

Rattus norvegicus interactions

Pathogen Info	Bact Prot Annot	Identifier A	Gene A	Taxon A	Identifier B	Gene B	Taxon B	PubMed	Interaction Type	Detection Method	MI Score	mnt interaction id	Annotations
who priority: NULL hazard_group: 2	Exotoxin	P0DPI0	botA Clostridium botulinum	1491	Q9Z2I6	Sv2c Rattus norvegicus	10116	16545378	direct interaction	pull down	0.62	mentha:MNT-10116-1	11100
who priority: NULL hazard_group: 2	Exotoxin	P10844	botB Clostridium botulinum	1491	P29101	Syt2 Rattus norvegicus	10116	16545378	direct interaction	pull down	0.77	mentha:MNT-10116-2	11100
who priority: NULL hazard_group: 2	Exotoxin	A5JGM8	bont Clostridium botulinum	1491	P21707	Syt1 Rattus norvegicus	10116	23932591	association	pull down	0.35	mentha:MNT-10116-3	11100
who priority: NULL hazard_group: 2	Exotoxin	A5JGM8	bont Clostridium botulinum	1491	P29101	Syt2 Rattus norvegicus	10116	23932591	association	pull down	0.52	mentha:MNT-10116-4	11100
who priority: NULL hazard_group: 2	Exotoxin	A5JGM8	bont Clostridium botulinum	1491	P29101	Syt2 Rattus norvegicus	10116	23932591	direct interaction	x-ray crystallography	0.52	mentha:MNT-10116-5	11100
who priority: critical hazard_group: 3	Effector delivery system, Type 3 secretion system	P0DJ88	espF(U) Escherichia coli O157:H7	83334	O08816	Wasl Rattus norvegicus	10116	18650806	direct interaction	pull down	0.62	mentha:MNT-10116-6	11100
who priority: critical hazard_group: 3	Effector delivery system, Type 3 secretion system	P0DJ88	espF(U) Escherichia coli O157:H7	83334	O08816	Wasl Rattus norvegicus	10116	18650806	direct interaction	fluorescence polarization spectroscopy	0.62	mentha:MNT-10116-7	11100
who priority: critical hazard_group: 3	Effector delivery system, Type 3 secretion system	P0DJ88	espF(U) Escherichia coli O157:H7	83334	O08816	Wasl Rattus norvegicus	10116	18650806	direct interaction	cosedimentation in solution	0.62	mentha:MNT-10116-8	11100
who priority: critical hazard_group: 2	Effector delivery system, Type 3 secretion system	B7UR60	E2348C_1442 Escherichia coli O127:H6	574521	P31016	Dlg4 Rattus norvegicus	10116	17979986	direct interaction	protein array	0.44	mentha:MNT-10116-9	11100
who priority: critical hazard_group: 2	Effector delivery system, Type 3 secretion system	B7UR60	E2348C_1442 Escherichia coli O127:H6	574521	Q62696	Dlg1 Rattus norvegicus	10116	17979986	direct interaction	protein array	0.44	mentha:MNT-10116-10	11100
who priority: critical hazard_group: 2	Effector delivery system, Type 3 secretion system	B7UR60	E2348C_1442 Escherichia coli O127:H6	574521	Q62936	Dlg3 Rattus norvegicus	10116	17979986	direct interaction	protein array	0.44	mentha:MNT-10116-11	10100
who priority: NULL hazard_group: 2	Invasion	Q2GL86	APH_0248 Anaplasma phagocytophilum	212042	P04785	P4hb Rattus norvegicus	10116	31992623	physical association	pull down	0.4	mentha:MNT-10116-12	11000
who priority: NULL hazard_group: 2	Exotoxin	P10844	botB Clostridium botulinum	1491	P29101	Syt2 Rattus norvegicus	10116	22265973	direct interaction	pull down	0.77	mentha:MNT-10116-13	11100
who priority: NULL hazard_group: 2	Exotoxin	Q60393	botG Clostridium botulinum	1491	P29101	Syt2 Rattus norvegicus	10116	22265973	direct interaction	pull down	0.44	mentha:MNT-10116-14	11100
who priority: critical hazard_group: 2	-	P0ABE7	cybC Escherichia coli	562	P54311	Gnb1 Rattus norvegicus	10116	29899450	physical association	3D electron microscopy	0.49	mentha:MNT-10116-15	01000
who priority: critical hazard_group: 2	-	P0ABE7	cybC Escherichia coli	562	P54311	Gnb1 Rattus norvegicus	10116	29899450	physical association	molecular sieving	0.49	mentha:MNT-10116-16	01000
who priority: critical hazard_group: 3	Effector delivery system, Type 3 secretion system	Q8X482	espF(U) Escherichia coli O157:H7	83334	O08816	Wasl Rattus norvegicus	10116	18974829	physical association	two hybrid	0.76	mentha:MNT-10116-17	11100
who priority: critical hazard_group: 3	Effector delivery system, Type 3 secretion system	Q8X482	espF(U) Escherichia coli O157:H7	83334	O08816	Wasl Rattus norvegicus	10116	18974829	direct interaction	isothermal titration calorimetry	0.76	mentha:MNT-10116-18	11100
who priority: critical hazard_group: 3	Effector delivery system, Type 3 secretion system	Q8X482	espF(U) Escherichia coli O157:H7	83334	O08816	Wasl Rattus norvegicus	10116	18974829	association	molecular sieving	0.76	mentha:MNT-10116-19	11100
who priority: critical hazard_group: 3	Effector delivery system, Type 3 secretion system	Q8X482	espF(U) Escherichia coli O157:H7	83334	O08816	Wasl Rattus norvegicus	10116	15296718	physical association	two hybrid	0.76	mentha:MNT-10116-20	11100
who priority: critical hazard_group: 3	Effector delivery system, Type 3 secretion system	Q8X482	espF(U) Escherichia coli O157:H7	83334	O08816	Wasl Rattus norvegicus	10116	17451412	physical association	two hybrid	0.76	mentha:MNT-10116-21	11000
who priority: NULL hazard_group: 2	Effector delivery system, Type 4 secretion system	Q5ZWW6	lpg0968 Legionella pneumophila subsp. pneumophila	272624	B0K022	Atp6v0b Rattus norvegicus	10116	32165585	physical association	electron microscopy 3D single particle reconstruction	0.32	mentha:MNT-10116-22	11100
who priority: NULL hazard_group: 2	Effector delivery system, Type 4 secretion system	Q5ZWW6	lpg0968 Legionella pneumophila subsp. pneumophila	272624	D4A133	Atp6v1a Rattus norvegicus	10116	32165585	physical association	mass spectrometry studies of complexes	0.4	mentha:MNT-10116-23	11100
who priority: NULL hazard_group: 2	Exotoxin	P0DPI0	botA Clostridium botulinum	1491	Q9Z2I6	Sv2c Rattus norvegicus	10116	24583011	direct interaction	pull down	0.62	mentha:MNT-10116-24	11100
who priority: NULL hazard_group: 2	Exotoxin	P0DPI0	botA Clostridium botulinum	1491	Q02563	Sv2a Rattus norvegicus	10116	24583011	direct interaction	pull down	0.54	mentha:MNT-10116-25	11100
who priority: NULL hazard_group: 2	Exotoxin	P0DPI0	botA Clostridium botulinum	1491	Q9Z2I6	Sv2c Rattus norvegicus	10116	24583011	direct interaction	pull down	0.62	mentha:MNT-10116-26	11100
who priority: NULL hazard_group: 2	Exotoxin	P0DPI0	botA Clostridium botulinum	1491	Q02563	Sv2a Rattus norvegicus	10116	24583011	physical association	anti tag coimmunoprecipitation	0.54	mentha:MNT-10116-27	11100
who priority: NULL hazard_group: 2	Exotoxin	P0DPI0	botA Clostridium botulinum	1491	Q63564	Sv2b Rattus norvegicus	10116	24583011	physical association	anti tag coimmunoprecipitation	0.4	mentha:MNT-10116-28	11100
who priority: NULL hazard_group: 2	Exotoxin	Q00496	botE Clostridium botulinum	1491	Q02563	Sv2a Rattus norvegicus	10116	24583011	physical association	anti tag coimmunoprecipitation	0.4	mentha:MNT-10116-29	11100
who priority: NULL hazard_group: 2	Exotoxin	Q00496	botE Clostridium botulinum	1491	Q63564	Sv2b Rattus norvegicus	10116	24583011	physical association	anti tag coimmunoprecipitation	0.4	mentha:MNT-10116-30	11100
who priority: NULL hazard_group: 2	Exotoxin	P30996	botF Clostridium botulinum	1491	Q63564	Sv2b Rattus norvegicus	10116	24583011	physical association	anti tag coimmunoprecipitation	0.4	mentha:MNT-10116-31	11100
who priority: NULL hazard_group: 2	Exotoxin	P30996	botF Clostridium botulinum	1491	Q02563	Sv2a Rattus norvegicus	10116	24583011	physical association	anti tag coimmunoprecipitation	0.4	mentha:MNT-10116-32	11100
who priority: NULL hazard_group: 2	Exotoxin	P10844	botB Clostridium botulinum	1491	P21707	Syt1 Rattus norvegicus	10116	17167418	physical association	pull down	0.4	mentha:MNT-10116-33	11100
who priority: NULL hazard_group: 2	Exotoxin	P10844	botB Clostridium botulinum	1491	P29101	Syt2 Rattus norvegicus	10116	17167421	direct interaction	isothermal titration calorimetry	0.77	mentha:MNT-10116-34	11100
who priority: NULL hazard_group: 2	Exotoxin	P10844	botB Clostridium botulinum	1491	P29101	Syt2 Rattus norvegicus	10116	17167421	direct interaction	pull down	0.77	mentha:MNT-10116-35	11100

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